XBP1

Gene Symbol	XBP1
Entrez Gene	7494
Alt Symbol	TREB-5, TREB5, XBP-1, XBP2
Species	Human
Gene Type	protein-coding
Description	X-box binding protein 1
Other Description	X-box-binding protein 1|tax-responsive element-binding protein 5
Swissprots	Q969P1 Q96BD7 P17861 Q8WYK6
Accessions	CAA39149 EAW59763 EAW59764 EAW59765 P17861 AB076383 BAB82981 AB076384 BAB82982 AK093842 AK292188 BAF84877 AK313761 AM393640 CAL38516 BC000938 AAH00938 BC012841 AAH12841 BC015709 AAH15709 BI545390 CR456611 CAG30497 CU013207 CAK54638 CU013495 CAK54937 DQ890989 ABM81915 DQ894165 ABM85091 M31627 AAA36031 NM_001079539 NP_001073007 NM_005080 NP_005071
Function	Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis
Subcellular Location	Isoform 2: Nucleus {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin- dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}.
Tissue Specificity	Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). {ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:25280941}.
Top Pathways	Protein processing in endoplasmic reticulum, HTLV-I infection, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

XBP-1s (D2C1F) Rabbit mAb - 12782 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D2C1F

XBP-1 (L-13) - sc-32135 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

XBP-1 (M-186) - sc-7160 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

XBP-1 (R-14) - sc-32136 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

XBP-1U (C-20) - sc-32138 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-XBP1 antibody - ab37152 from Abcam Prices $401.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-XBP1 antibody - ab37151 from Abcam Prices $382.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-XBP1 antibody - ab85546 from Abcam Prices $378.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-XBP1 antibody - ab28715 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-XBP1 antibody - ab198999 from Abcam Prices $376.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-XBP1 antibody - ab155055 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-XBP1 antibody - ab76443 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-XBP1 antibody - ab76865 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-XBP1 antibody - ab37645 from Abcam Prices $376.00 Sizes 50 µg Host Chicken Clonality Polyclonal

Anti-XBP1 antibody [3H1G4] - ab79724 from Abcam Prices $378.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3H1G4

Anti-XBP1 antibody [9B7E5] - ab109621 from Abcam Prices $384.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 9B7E5

Anti-XBP1 antibody [EPR4086] - ab109221 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4086

Anti-XBP1 antibody [XBP1H6E5] - ab50900 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone XBP1H6E5

Anti-XBP1 Antibody (N-Terminus) - LS-C18554 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-XBP1 Antibody (C-Terminus) - LS-C40271 from LifeSpan Bioscience Prices $590.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-XBP1 Antibody - LS-C76883 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-XBP1 Antibody (N-Terminus) - LS-C90740 from LifeSpan Bioscience Prices $545.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-XBP1 Antibody (N-Terminus, Azide-free) - LS-C122553 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-XBP1 Antibody (C-Terminus) - LS-C79964 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-XBP1 Antibody (aa38-87) - LS-C80215 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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