XBP1

Gene Symbol	XBP1
Entrez Gene	7494
Alt Symbol	TREB-5, TREB5, XBP-1, XBP2
Species	Human
Gene Type	protein-coding
Description	X-box binding protein 1
Other Description	X-box-binding protein 1|tax-responsive element-binding protein 5
Swissprots	Q969P1 Q96BD7 P17861 Q8WYK6
Accessions	CAA39149 EAW59763 EAW59764 EAW59765 P17861 AB076383 BAB82981 AB076384 BAB82982 AK093842 AK292188 BAF84877 AK313761 AM393640 CAL38516 BC000938 AAH00938 BC012841 AAH12841 BC015709 AAH15709 BI545390 CR456611 CAG30497 CU013207 CAK54638 CU013495 CAK54937 DQ890989 ABM81915 DQ894165 ABM85091 M31627 AAA36031 NM_001079539 NP_001073007 NM_005080 NP_005071
Function	Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis
Subcellular Location	Isoform 2: Nucleus {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin- dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}.
Tissue Specificity	Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). {ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:25280941}.
Top Pathways	Protein processing in endoplasmic reticulum, HTLV-I infection, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human XBP1 full length protein - ab40096 from Abcam Category Protein Source E. coli Species Human

Human XBP1 peptide - ab39909 from Abcam Category Peptide Species Human

Human XBP1 peptide - ab39910 from Abcam Category Peptide Species Human

Human XBP1 peptide - ab30769 from Abcam Category Peptide

XBP1 Antibody Blocking Peptide - LS-E1946 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XBP1 Antibody Blocking Peptide - LS-E30209 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

XBP1 Antibody Blocking Peptide - LS-E30208 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

XBP1 Antibody Blocking Peptide - LS-E7728 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XBP1 Antibody Blocking Peptide - LS-E10989 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XBP1 Antibody Blocking Peptide - LS-E13869 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XBP1 Antibody Blocking Peptide - LS-E26726 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human XBP1 Protein - H00007494-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

XBP1 Blocking Peptide - NBP1-77253PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

XBP1 Blocking Peptide - NBP1-77252PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

XBP1-Antibody-C-term-Blocking-peptide - BP12798b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XBP1-Antibody-Center-Blocking-Peptide - BP5088c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XBP1 Recombinant Protein - GTX48114-PRO from GeneTex Category Protein Prices $299.00 Sizes 50 μg Source E. coli Species Human

XBP1 blocking peptide - GTX88727-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

XBP1 Protein Lysate (APL10373) - APL10373 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

XBP1 Protein Lysate (APL10374) - APL10374 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

XBP1 Immunizing peptide - orb50472 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

XBP1 Peptide - AC21-1564-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

XBP1 / TREB5 - H00007494-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

XBP1 / TREB5 Control Peptide - AP30990CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

XBP1 / TREB5 Control Peptide - AP30991CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

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