XBP1

Gene Symbol	XBP1
Entrez Gene	7494
Alt Symbol	TREB-5, TREB5, XBP-1, XBP2
Species	Human
Gene Type	protein-coding
Description	X-box binding protein 1
Other Description	X-box-binding protein 1|tax-responsive element-binding protein 5
Swissprots	Q969P1 Q96BD7 P17861 Q8WYK6
Accessions	CAA39149 EAW59763 EAW59764 EAW59765 P17861 AB076383 BAB82981 AB076384 BAB82982 AK093842 AK292188 BAF84877 AK313761 AM393640 CAL38516 BC000938 AAH00938 BC012841 AAH12841 BC015709 AAH15709 BI545390 CR456611 CAG30497 CU013207 CAK54638 CU013495 CAK54937 DQ890989 ABM81915 DQ894165 ABM85091 M31627 AAA36031 NM_001079539 NP_001073007 NM_005080 NP_005071
Function	Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis
Subcellular Location	Isoform 2: Nucleus {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin- dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}.
Tissue Specificity	Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). {ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:25280941}.
Top Pathways	Protein processing in endoplasmic reticulum, HTLV-I infection, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

XBP1-Over-expression-Lysate - LY14493a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

XBP1 293T Cell Transient Overexpression Lysate(Denatured) - H00007494-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

XBP1 overexpression lysate - LY421527 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

XBP1 overexpression lysate - LY425888 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

XBP1 293 Cell Lysate - 401422 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

XBP1 Overexpression Lysate (Denatured) - H00007494-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

XBP1 Overexpression Lysate (Native) - NBL1-17900 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

XBP1 Overexpression Lysate (Native) - NBP2-08472 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

XBP1 Overexpression Lysate (Native) - NBP2-09267 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

XBP-1 (h): 293 Lysate - sc-110810 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

XBP1 Over-expression Lysate Product - GWB-143232 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

XBP1 Overexpression Lysate (Denatured) - H00007494-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human XBP1 Knockdown Stable Cell Line - CSC-DC017561 from Creative biogene Category Cell Line Species Human

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