| Gene Symbol |
XBP1
|
| Entrez Gene |
7494
|
| Alt Symbol |
TREB-5, TREB5, XBP-1, XBP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
X-box binding protein 1
|
| Other Description |
X-box-binding protein 1|tax-responsive element-binding protein 5
|
| Swissprots |
Q969P1 Q96BD7 P17861 Q8WYK6
|
| Accessions |
CAA39149 EAW59763 EAW59764 EAW59765 P17861 AB076383 BAB82981 AB076384 BAB82982 AK093842 AK292188 BAF84877 AK313761 AM393640 CAL38516 BC000938 AAH00938 BC012841 AAH12841 BC015709 AAH15709 BI545390 CR456611 CAG30497 CU013207 CAK54638 CU013495 CAK54937 DQ890989 ABM81915 DQ894165 ABM85091 M31627 AAA36031 NM_001079539 NP_001073007 NM_005080 NP_005071
|
| Function |
Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis
|
| Subcellular Location |
Isoform 2: Nucleus {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin- dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}.
|
| Tissue Specificity |
Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). {ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:25280941}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum, HTLV-I infection, Non-alcoholic fatty liver disease (NAFLD)
|