Gene Symbol | EPCAM |
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Entrez Gene | 4072 |
Alt Symbol | DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1 |
Species | Human |
Gene Type | protein-coding |
Description | epithelial cell adhesion molecule |
Other Description | adenocarcinoma-associated antigen|cell surface glycoprotein Trop-1|epithelial glycoprotein 314|human epithelial glycoprotein-2|major gastrointestinal tumor-associated protein GA733-2|membrane component, chromosome 4, surface marker (35kD glycoprotein)|tumor-associated calcium signal transducer 1 |
Swissprots | P16422 Q9UCD0 Q6FG49 Q96C47 Q6FG26 P18180 |
Accessions | AAB00775 AAY15095 CAG28087 EAX00218 EAX00219 P16422 AK026585 AW050533 BC014785 AAH14785 BP262680 CR542259 CAG47055 CR542283 CAG47078 DA963872 DB044092 DQ891338 ABM82264 DQ894520 ABM85446 M26481 AAA59543 M32306 AAA35723 M32325 AAA36151 M33011 AAA35861 X14758 CAA32870 NM_002354 NP_002345 |
Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:15922867, ECO:0000269|PubMed:19785009, ECO:0000269|PubMed:20064925}. |
Subcellular Location | Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. |
Tissue Specificity | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. {ECO:0000269|PubMed:20064925}. |
EpCAM (VU1D9) Mouse mAb (Pacific Blue™ Conjugate) - 9032 from Cell Signaling Technology
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EpCAM (VU1D9) Mouse mAb (PE Conjugate) - 8995 from Cell Signaling Technology
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EpCAM (VU1D9) Mouse mAb (Alexa Fluor ® 488 Conjugate) - 5198 from Cell Signaling Technology
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EpCAM (VU1D9) Mouse mAb (Alexa Fluor ® 594 Conjugate) - 7319 from Cell Signaling Technology
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EpCAM (VU1D9) Mouse mAb (Alexa Fluor ® 555 Conjugate) - 5488 from Cell Signaling Technology
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EpCAM (VU1D9) Mouse mAb (Alexa Fluor ® 647 Conjugate) - 5447 from Cell Signaling Technology
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EpCAM (D1B3) Rabbit mAb - 2626 from Cell Signaling Technology
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EpCAM (VU1D9) Mouse mAb - 2929 from Cell Signaling Technology
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EpCAM (D9S3P) Rabbit mAb (IHC Preferred) - 14452 from Cell Signaling Technology
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EpCAM Antibody - 3599 from Cell Signaling Technology
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CA215 (RP 215) - sc-69849 from Santa Cruz Biotechnology
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Ep-CAM (C-10) - sc-25308 from Santa Cruz Biotechnology
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Ep-CAM (A-20) - sc-23788 from Santa Cruz Biotechnology
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Ep-CAM (H-70) - sc-20154 from Santa Cruz Biotechnology
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Ep-CAM (9C4) - sc-21792 from Santa Cruz Biotechnology
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Ep-CAM (KS1/4) - sc-33687 from Santa Cruz Biotechnology
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Ep-CAM (EBA-1) - sc-66020 from Santa Cruz Biotechnology
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Ep-CAM (VU-1D9) - sc-51681 from Santa Cruz Biotechnology
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Ep-CAM (AUA1) - sc-53277 from Santa Cruz Biotechnology
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Ep-CAM (HEA125) - sc-59906 from Santa Cruz Biotechnology
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Ep-CAM (323/A3) - sc-73491 from Santa Cruz Biotechnology
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Ep-CAM (B302) - sc-59783 from Santa Cruz Biotechnology
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Ep-CAM (0.N.276) - sc-71059 from Santa Cruz Biotechnology
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Ep-CAM (5F209) - sc-71057 from Santa Cruz Biotechnology
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Ep-CAM (3H2141) - sc-71056 from Santa Cruz Biotechnology
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