Gene Symbol | EPCAM |
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Entrez Gene | 4072 |
Alt Symbol | DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1 |
Species | Human |
Gene Type | protein-coding |
Description | epithelial cell adhesion molecule |
Other Description | adenocarcinoma-associated antigen|cell surface glycoprotein Trop-1|epithelial glycoprotein 314|human epithelial glycoprotein-2|major gastrointestinal tumor-associated protein GA733-2|membrane component, chromosome 4, surface marker (35kD glycoprotein)|tumor-associated calcium signal transducer 1 |
Swissprots | P16422 Q9UCD0 Q6FG49 Q96C47 Q6FG26 P18180 |
Accessions | AAB00775 AAY15095 CAG28087 EAX00218 EAX00219 P16422 AK026585 AW050533 BC014785 AAH14785 BP262680 CR542259 CAG47055 CR542283 CAG47078 DA963872 DB044092 DQ891338 ABM82264 DQ894520 ABM85446 M26481 AAA59543 M32306 AAA35723 M32325 AAA36151 M33011 AAA35861 X14758 CAA32870 NM_002354 NP_002345 |
Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:15922867, ECO:0000269|PubMed:19785009, ECO:0000269|PubMed:20064925}. |
Subcellular Location | Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. |
Tissue Specificity | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. {ECO:0000269|PubMed:20064925}. |
TROP1 (EpCAM) Human ELISA Kit - ab155442 from Abcam
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Human TACSTD1 / EPCAM ELISA Kit (Sandwich ELISA) - LS-F4660 from LifeSpan Bioscience
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Human TACSTD1 / EPCAM ELISA Kit (Sandwich ELISA) - LS-F204 from LifeSpan Bioscience
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Human TROP1 / EpCAM ELISA Kit - RAB0172 from Sigma-Aldrich
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Human EpCAM/TROP1 DuoSet ELISA - DY960 from R&D Systems
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Human EPCAM ELISA Kit - abx151423 from Abbexa
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Epithelial Cell Adhesion Molecule, Ep-CAM/CD326, Human, ELISA Kit - E-EL-H1880 from ARP American Research Products
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Epithelial Cell Adhesion Molecule (EPCAM), Human, ELISA Kit - SEB283Hu from ARP American Research Products
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Epithelial cell adhesion molecule (TACSTD1), Human, ELISA Kit - E01E0395 from ARP American Research Products
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Epithelial cell adhesion molecule, EPCAM, Human, ELISA Kit - E1283h from ARP American Research Products
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Epithelial Cell Adhesion Molecule, Human, ELISA Kit - E01E0056 from ARP American Research Products
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Epithelial Cell Adhesion Molecule, EPCAM, Mouse, ELISA Kit - E-EL-M0470 from ARP American Research Products
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Epithelial Cell Adhesion Molecule, Ep-CAM/CD326, Rabbit, ELISA Kit - E-EL-RB1474 from ARP American Research Products
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Epithelial Cell Adhesion Molecule, Ep-CAM/CD326, Chicken, ELISA Kit - E-EL-Ch1722 from ARP American Research Products
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Epithelial Cell Adhesion Molecule, Ep-CAM/CD326, Porcine, ELISA Kit - E-EL-P1345 from ARP American Research Products
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Epithelial Cell Adhesion Molecule, Ep-CAM/CD326, Monkey, ELISA Kit - E-EL-MK2232 from ARP American Research Products
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Human TROP1 ELISA - ELH-TROP1 from RayBiotech
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Human EPCAM ELISA Kit - HE0063 from NeoScientific
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Anserine EPCAM ELISA Kit - AE0063 from NeoScientific
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Epithelial Cell Adhesion Molecule, ELISA Kit - MBS048131 from MyBioSource
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Epithelial Cell Adhesion Molecule, ELISA Kit - MBS009233 from MyBioSource
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Epithelial Cell Adhesion Molecule, ELISA Kit - MBS077592 from MyBioSource
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Epithelial Cell Adhesion Molecule, ELISA Kit - MBS019481 from MyBioSource
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Epithelial Cell Adhesion Molecule, ELISA Kit - MBS015402 from MyBioSource
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Epithelial Cell Adhesion Molecule, ELISA Kit - MBS006450 from MyBioSource
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