Gene Symbol | EPCAM |
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Entrez Gene | 4072 |
Alt Symbol | DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1 |
Species | Human |
Gene Type | protein-coding |
Description | epithelial cell adhesion molecule |
Other Description | adenocarcinoma-associated antigen|cell surface glycoprotein Trop-1|epithelial glycoprotein 314|human epithelial glycoprotein-2|major gastrointestinal tumor-associated protein GA733-2|membrane component, chromosome 4, surface marker (35kD glycoprotein)|tumor-associated calcium signal transducer 1 |
Swissprots | P16422 Q9UCD0 Q6FG49 Q96C47 Q6FG26 P18180 |
Accessions | AAB00775 AAY15095 CAG28087 EAX00218 EAX00219 P16422 AK026585 AW050533 BC014785 AAH14785 BP262680 CR542259 CAG47055 CR542283 CAG47078 DA963872 DB044092 DQ891338 ABM82264 DQ894520 ABM85446 M26481 AAA59543 M32306 AAA35723 M32325 AAA36151 M33011 AAA35861 X14758 CAA32870 NM_002354 NP_002345 |
Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:15922867, ECO:0000269|PubMed:19785009, ECO:0000269|PubMed:20064925}. |
Subcellular Location | Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. |
Tissue Specificity | Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. {ECO:0000269|PubMed:20064925}. |
Ep-CAM CRISPR/Cas9 KO Plasmid (h) - sc-400220 from Santa Cruz Biotechnology
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Ep-CAM HDR Plasmid (h) - sc-400220-HDR from Santa Cruz Biotechnology
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Ep-CAM Double Nickase Plasmid (h) - sc-400220-NIC from Santa Cruz Biotechnology
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Ep-CAM Double Nickase Plasmid (h2) - sc-400220-NIC-2 from Santa Cruz Biotechnology
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Ep-CAM CRISPR Activation Plasmid (h) - sc-400220-ACT from Santa Cruz Biotechnology
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Ep-CAM CRISPR Activation Plasmid (h2) - sc-400220-ACT-2 from Santa Cruz Biotechnology
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Ep-CAM Lentiviral Activation Particles (h) - sc-400220-LAC from Santa Cruz Biotechnology
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Ep-CAM Lentiviral Activation Particles (h2) - sc-400220-LAC-2 from Santa Cruz Biotechnology
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Ep-CAM siRNA (h) - sc-43032 from Santa Cruz Biotechnology
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Ep-CAM shRNA Plasmid (h) - sc-43032-SH from Santa Cruz Biotechnology
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Ep-CAM shRNA (h) Lentiviral Particles - sc-43032-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU037851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2075 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2075 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04403 from Sigma-Aldrich
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EPCAM siRNA (Human) - CRH2761 from Cohesion Biosciences
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EPCAM - MBS8227454 from MyBioSource
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Human EPCAM siRNA - orb263263 from Biorbyt
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EPCAM shRNA Plasmid (Human) - CHH2761 from Cohesion Biosciences
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EPCAM miRNA 3'UTR clone - MiUTR3H-02150 from Creative biogene
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