EPCAM

Gene Symbol EPCAM
Entrez Gene 4072
Alt Symbol DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1
Species Human
Gene Type protein-coding
Description epithelial cell adhesion molecule
Other Description adenocarcinoma-associated antigen|cell surface glycoprotein Trop-1|epithelial glycoprotein 314|human epithelial glycoprotein-2|major gastrointestinal tumor-associated protein GA733-2|membrane component, chromosome 4, surface marker (35kD glycoprotein)|tumor-associated calcium signal transducer 1
Swissprots P16422 Q9UCD0 Q6FG49 Q96C47 Q6FG26 P18180
Accessions AAB00775 AAY15095 CAG28087 EAX00218 EAX00219 P16422 AK026585 AW050533 BC014785 AAH14785 BP262680 CR542259 CAG47055 CR542283 CAG47078 DA963872 DB044092 DQ891338 ABM82264 DQ894520 ABM85446 M26481 AAA59543 M32306 AAA35723 M32325 AAA36151 M33011 AAA35861 X14758 CAA32870 NM_002354 NP_002345
Function May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:15922867, ECO:0000269|PubMed:19785009, ECO:0000269|PubMed:20064925}.
Subcellular Location Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction.
Tissue Specificity Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma. {ECO:0000269|PubMed:20064925}.

Human-TACSTD1-cDNA-Clone - DC03934 from Abgent, a WuXi AppTec company

Prices $423.90
Sizes 10 µg
Species Human
Accession BC014785

Human EpCAM ORF clone(NM_002354.2) - CDCL184058 from Creative Biomart

Species Human
Accession NM_002354.2

Mouse EpCAM/TROP1 (NP_032558) VersaClone cDNA - RDC1282 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Mouse

Mouse IL-11 R alpha (NP_034679) VersaClone cDNA - RDC1472 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Mouse

Human EpCAM/TROP1 (NP_002345) VersaClone cDNA - RDC1470 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Human
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