| Gene Symbol |
IFNL1
|
| Entrez Gene |
282618
|
| Alt Symbol |
IL-29, IL29
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon, lambda 1
|
| Other Description |
IFN-lambda-1|cytokine Zcyto21|interferon lambda-1|interferon-lambda-1|interleukin 29 (interferon, lambda 1)|interleukin-29
|
| Swissprots |
Q17R34 A0AV25 Q8IU54
|
| Accessions |
CAI75183 CAJ41836 CAL33802 CAL68893 CAL68894 CAS97664 CAT00937 CAT00938 CAT02302 CBI85489 CBI85490 CBY45348 CBY45408 CDL78891 EAW56871 Q8IU54 AY129150 AAN28265 AY184372 AAN86125 AY336716 AAR24511 BC074985 AAH74985 BC117482 AAI17483 BC126183 AAI26184 HQ214053 ADO12077 HQ258085 ADR82839 JF268782 AEV89427 NM_172140 NP_742152
|
| Function |
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|
![Western Blot: IL29 Overexpression Lysate (Adult Normal) [NBP2-05199] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IL29.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5797_IL29%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05199-img0001.jpg)