IFNL1

Gene Symbol IFNL1
Entrez Gene 282618
Alt Symbol IL-29, IL29
Species Human
Gene Type protein-coding
Description interferon, lambda 1
Other Description IFN-lambda-1|cytokine Zcyto21|interferon lambda-1|interferon-lambda-1|interleukin 29 (interferon, lambda 1)|interleukin-29
Swissprots Q17R34 A0AV25 Q8IU54
Accessions CAI75183 CAJ41836 CAL33802 CAL68893 CAL68894 CAS97664 CAT00937 CAT00938 CAT02302 CBI85489 CBI85490 CBY45348 CBY45408 CDL78891 EAW56871 Q8IU54 AY129150 AAN28265 AY184372 AAN86125 AY336716 AAR24511 BC074985 AAH74985 BC117482 AAI17483 BC126183 AAI26184 HQ214053 ADO12077 HQ258085 ADR82839 JF268782 AEV89427 NM_172140 NP_742152
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Subcellular Location Secreted.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

IL-28/29 (H-1) - sc-365834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-28/29 (H-1): sc-365834. Western blot analysis of human recombinant IL-28/29.

IL-29 (K-13) - sc-67643 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-29 (C-19) - sc-67642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-29 (C-19): sc-67642. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing cytoplasmic staining of neuronal cell and glial cells.

IL-29 (B-21) - sc-130787 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
IL-29 (B-21): sc-130787. Western blot analysis of IL-29 expression in Jurkat whole cell lysate.

Anti-IL29 antibody - ab38569 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-IL29 antibody (ab38569) at 1/100 dilution + Jurkat cell lysate

Anti-IL29 antibody - ab111990 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL29 antibody (ab111990) at 1/500 dilutionLane 1 : Human fetal liver lysateLane 2 : Human fetal brain lysate

Anti-IL29 antibody - ab190609 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL29 antibody (ab190609) at 1/500 dilution + extracts from L929 cells at 30 µg

Anti-IL29 antibody - ab106137 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IL29 antibody (ab106137) at 1/1000 dilution + Recombinant protein (immunogen) at 0.1 µgSecondaryDylight™ 649 Conjugated Anti-Rabbit IgG (H&L) at 1/20000 dilution

Anti-IFNL1 / IL29 Antibody (aa62-91, APC) - LS-C244783 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (aa62-91, Biotin) - LS-C244784 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (aa62-91, AP) - LS-C244782 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (aa62-91, FITC) - LS-C244785 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody - LS-C154098 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Human IL-29 Antibody - Western Blot. Anti-human IL-29 antibody in western blot shows detection of recombinant human IL-29 raised in E. coli. Recombinant protein (0.1 ug, 19.9 kD) was loaded onto and resolved by SDS-PAGE, then transferred to nitrocellulose. The membrane was blocked with 1% BSA in TBST for 30 min at RT, followed by incubation with Anti-Human IL-29. After washing, membrane was probed with secondary antibody Dylight 649 Conjugated Anti-Rabbit IgG (H&L) (Goat) Antibody ( diluted 1:20000 in blocking buffer (MB-070) for 30 min. at RT. Data was collected using Bio-Rad VersaDoc 4000 MP imaging system.

Anti-IFNL1 / IL29 Antibody (N-Terminus, AP) - LS-C244786 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (N-Terminus, Biotin) - LS-C244788 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (N-Terminus, APC) - LS-C244787 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (N-Terminus, FITC) - LS-C244790 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (N-Terminus, PE) - LS-C244791 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (aa62-91, PE) - LS-C244789 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (aa62-91, Azide-free, HRP) - LS-C247653 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (N-Terminus, Azide-free, HRP) - LS-C247654 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (N-Terminus) - LS-C330483 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (aa23-200) - LS-C178564 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IFNL1 / IL29 Antibody (aa54-85) - LS-C97859 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-IFNL1 / IL29 Antibody IHC-plus™ - LS-B9452 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IFNL1 / IL29 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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