IFNL1

Gene Symbol	IFNL1
Entrez Gene	282618
Alt Symbol	IL-29, IL29
Species	Human
Gene Type	protein-coding
Description	interferon, lambda 1
Other Description	IFN-lambda-1|cytokine Zcyto21|interferon lambda-1|interferon-lambda-1|interleukin 29 (interferon, lambda 1)|interleukin-29
Swissprots	Q17R34 A0AV25 Q8IU54
Accessions	CAI75183 CAJ41836 CAL33802 CAL68893 CAL68894 CAS97664 CAT00937 CAT00938 CAT02302 CBI85489 CBI85490 CBY45348 CBY45408 CDL78891 EAW56871 Q8IU54 AY129150 AAN28265 AY184372 AAN86125 AY336716 AAR24511 BC074985 AAH74985 BC117482 AAI17483 BC126183 AAI26184 HQ214053 ADO12077 HQ258085 ADR82839 JF268782 AEV89427 NM_172140 NP_742152
Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Subcellular Location	Secreted.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL29 full length protein - ab155625 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source HEK 293 cells Species Human

Active human IL29 full length protein - ab50032 from Abcam Category Protein Prices $110.00, $257.00 Sizes 5 µg, 20 µg Source E. coli Species Human

Active human IL29 full length protein - ab191738 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Human

Active human IL29 protein fragment - ab200263 from Abcam Category Protein Prices $101.00 Sizes 5 µg Source E. coli Species Human

Human IL29 full length protein - ab194167 from Abcam Category Protein Source Mammalian Species Human

Human IL29 full length protein - ab202252 from Abcam Category Protein Source E. coli Species Human

Human IL29 full length protein - ab117683 from Abcam Category Protein Source E. coli Species Human

IFNL1 / IL29 Antibody Blocking Peptide - LS-E4727 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-29/IFN-lambda 1 Protein - NBP2-34996 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

IL-29/IFN-lambda 1 Recombinant Protein - P3635 from Novus Biologicals Category Protein Prices $369.00 Sizes 20 µg Species Human

IL-29/IFN-lambda 1 Peptide - P0624 from Novus Biologicals Category Peptide Species Human

IL29-Antibody-Center-Blocking-Peptide - BP1709b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IL29 Recombinant Protein (Active) - GTX48236-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

IL29 recombinant protein - GTX65471 from GeneTex Category Protein Prices $249.00 Sizes 20 μg Source E. coli Species Human

Recombinant Human IL-29/IFN-lambda 1 - 1598-IL-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly20-Thr200, with a C-terminal 10-His tag

Recombinant Human IL-29/IFN-lambda 1, CF - 1598-IL-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly20-Thr200, with a C-terminal 10-His tag

IL 29 Protein (OPPA01640) - OPPA01640 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Recombinant IL-29 (OPSD00093) - OPSD00093 from Aviva Systems Biology Category Protein Prices $105.00 Sizes 5 µg

Human IL 29 protein - orb80476 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human IL29 protein - orb246588 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human IFNL1 protein - orb179675 from Biorbyt Category Protein Prices $298.00, $434.00 Sizes 20 μg, 50 μg Source Human Cells Species Human

Human IL 29 protein - orb84245 from Biorbyt Category Protein Prices $162.00, $323.00, $731.00 Sizes 5 μg, 20 μg, 100 μg Source Human Species Human

Human IL29 protein - orb82616 from Biorbyt Category Protein Prices $221.00, $357.00, $553.00, $910.00 Sizes 5 μg, 20 μg, 100 μg, 250 μg Source E.coli Species Human

IFN gamma 1 protein - 30R-AI068 from Fitzgerald Category Protein Prices $225.00 Sizes 20 µg Source E.coli

IFNL1 protein (His tag) - 80R-4089 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

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