IFNL1

Gene Symbol IFNL1
Entrez Gene 282618
Alt Symbol IL-29, IL29
Species Human
Gene Type protein-coding
Description interferon, lambda 1
Other Description IFN-lambda-1|cytokine Zcyto21|interferon lambda-1|interferon-lambda-1|interleukin 29 (interferon, lambda 1)|interleukin-29
Swissprots Q17R34 A0AV25 Q8IU54
Accessions CAI75183 CAJ41836 CAL33802 CAL68893 CAL68894 CAS97664 CAT00937 CAT00938 CAT02302 CBI85489 CBI85490 CBY45348 CBY45408 CDL78891 EAW56871 Q8IU54 AY129150 AAN28265 AY184372 AAN86125 AY336716 AAR24511 BC074985 AAH74985 BC117482 AAI17483 BC126183 AAI26184 HQ214053 ADO12077 HQ258085 ADR82839 JF268782 AEV89427 NM_172140 NP_742152
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Subcellular Location Secreted.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

IL-29 CRISPR/Cas9 KO Plasmid (h) - sc-403227 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-29 HDR Plasmid (h) - sc-403227-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-29 Double Nickase Plasmid (h) - sc-403227-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-29 Double Nickase Plasmid (h2) - sc-403227-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-29 CRISPR Activation Plasmid (h) - sc-403227-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-29 CRISPR Activation Plasmid (h2) - sc-403227-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-29 Lentiviral Activation Particles (h) - sc-403227-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-29 Lentiviral Activation Particles (h2) - sc-403227-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-29 siRNA (h) - sc-62499 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-29 shRNA Plasmid (h) - sc-62499-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-29 shRNA (h) Lentiviral Particles - sc-62499-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN10622 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10622 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00117 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00117

IFNL1 siRNA (Human) - CRJ6847 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IFNL1 - MBS8202444 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IL29 (NM_172140.1) - SHH318849 from Creative biogene

Category siRNA
Species Reactivities Human

Human IFNL1 siRNA - orb277348 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IFNL1 shRNA Plasmid (Human) - CHJ6847 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IL29 miRNA 3'UTR clone - MiUTR1H-04916 from Creative biogene

Species Reactivities Human
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