PDCD1LG2

Gene Symbol PDCD1LG2
Entrez Gene 80380
Alt Symbol B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2
Species Human
Gene Type protein-coding
Description programmed cell death 1 ligand 2
Other Description B7 dendritic cell molecule|B7-DC|PD-1 ligand 2|PD-1-ligand 2|PDCD1 ligand 2|butyrophilin B7-DC|programmed death ligand 2
Swissprots Q5T7Z6 Q6JXL8 Q9BQ51 Q6JXL9 Q14CN8
Accessions EAW58762 Q9BQ51 AF329193 AAK31105 AF344424 AAK15370 AK001872 AY254343 AAP13471 AY271901 AAP49000 AY271902 AAP49001 BC074766 AAH74766 BC113678 AAI13679 BC113680 AAI13681 BC143920 BC143921 BX951459 CA442083 DQ336699 ABC59616 EF444806 ABO33153 HQ258142 ADR82896 XM_005251600 XP_005251657 NM_025239 NP_079515
Function Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). {ECO:0000250}.
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. {ECO:0000269|PubMed:11224527}.
Top Pathways Cell adhesion molecules (CAMs)

Pdcd-1L2 (N-18) - sc-19096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pdcd-1L2 (N-18): sc-19096. Western blot analysis of Pdcd-1L2 expression in non-transfected: sc-117752 (A) and human Pdcd-1L2 transfected: sc-372943 (B) 293T whole cell lysates.

Pdcd-1L2 (XX19) - sc-80285 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Pdcd-1L2 (H-67) - sc-367730 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Pdcd-1L2 (H-67): sc-367730. Western blot analysis of Pdcd-1L2 expression in MCF7 (A), F9 (B), Raji (C), ZR-75-1 (D) and Hs 181 Tes (E) whole cell lysates.

Anti-B7 DC antibody - ab200377 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling B7 DC with ab200377 at 1/40 dilution.

Anti-B7 DC antibody - ab169104 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-B7 DC antibody (ab169104) at 1 µg/mlLane 1 : B7 DC-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L)-HRP at 1/7500 dilutiondeveloped using the ECL technique

Anti-B7 DC antibody [EPR1163(2)] - ab187662 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1163(2)
All lanes : Anti-B7 DC antibody [EPR1163(2)] (ab187662) at 1/10000 dilutionLane 1 : Raji cell lysateLane 2 : HepG2 cell lysateLane 3 : THP-1 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-B7 DC antibody [MIH14] - ab110182 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MIH14

Anti-B7 DC antibody [MIH14] (Phycoerythrin) - ab110184 from Abcam

Prices $188.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MIH14
ab110184 staining B7 DC in human peripheral blood monocytes by Flow cytometry.

Anti-B7 DC antibody - C-terminal - ab187332 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-B7 DC antibody - C-terminal (ab187332) at 1/1000 dilutionLane 1 : Mouse brain whole cell extract.Lane 2 : Mouse thymus whole cell extract.Lane 3 : HeLa whole cell extract.Lane 4 : Jurkat whole cell extract.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (PE) - LS-C128030 from LifeSpan Bioscience

Host Rat
Clonality Monoclonal

Anti-CD274 / B7-H1 / PD-L1 Antibody (clone MIH5, Biotin) - LS-C106180 from LifeSpan Bioscience

Prices $235.00, $305.00, $395.00
Sizes 50 µg, 100 µg, 500 µg
Host Rat
Clonality Monoclonal
Clone MIH5
Staining of C57Bl/6 splenocytes with 0.125 ug Biotin Rat IgG2a isotype control (open histogram) or 0.125 ug Biotin anti-mouse B7-H1 (MIH5, colored histogram) followed by Streptavidin-PE. Total viable cells were used for analysis.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody - LS-C150027 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (aa21-268, Biotin) - LS-C299528 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (aa21-268, FITC) - LS-C303608 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone 122, Biotin) - LS-C106659 from LifeSpan Bioscience

Prices $245.00, $305.00, $455.00
Sizes 50 µg, 100 µg, 500 µg
Host Rat
Clonality Monoclonal
Clone 122
Staining of in vitro BM-derived dendritic cells from BALB/c with 0.06 ug Biotin Rat IgG2a isotype control (open histogram) or 0.06 ug Biotin anti-mouse B7-DC (122, colored histogram) followed by Streptavidin-PE. Total viable cells were used for analysis.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone 122, PE) - LS-C106728 from LifeSpan Bioscience

Prices $255.00, $335.00, $415.00
Sizes 50 µg, 100 µg, 200 µg
Host Rat
Clonality Monoclonal
Clone 122
Staining of in vitro BM-derived dendritic cells from BALB/c with 0.125 ug PE Rat IgG2a isotype control (open histogram) or 0.06 ug PE anti-mouse B7-DC (122, colored histogram). Total viable cells were used for analysis.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone MIH14, FITC) - LS-C188355 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MIH14
Flow cytometry of human peripheral blood monocytes with Mouse anti-Human CD273:FITC

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone 122, FITC) - LS-C106135 from LifeSpan Bioscience

Prices $245.00, $315.00, $475.00
Sizes 50 µg, 100 µg, 500 µg
Host Rat
Clonality Monoclonal
Clone 122
Staining of in vitro BM-derived dendritic cells from BALB/c with 0.25 ug FITC Rat IgG2a isotype control (open histogram) or 0.25 ug FITC anti-mouse B7-DC (122, colored histogram). Total viable cells were used for analysis.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (aa20-219) - LS-C150224 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
PD-L2 in Mouse Thymus. PD-L2 was detected in perfusion fixed frozen sections of mouse thymus using 15 ug/ml Goat Anti-Mouse PD-L2 Antigen Affinity-purified Polyclonal Antibody overnight at 4°C. Tissue was stained with Anti-Goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone TY25) - LS-C107118 from LifeSpan Bioscience

Prices $235.00, $305.00, $405.00
Sizes 50 µg, 100 µg, 500 µg
Host Rat
Clonality Monoclonal
Clone TY25
Surface staining of B7-DC transfected cells with anti-mouse B7-DC (TY25) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone 8A4) - LS-C340012 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8A4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone 11F9) - LS-C340015 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11F9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone 54-1) - LS-C179483 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 54-1

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone TY25, PE) - LS-C106284 from LifeSpan Bioscience

Prices $255.00, $295.00, $395.00
Sizes 50 µg, 100 µg, 200 µg
Host Rat
Clonality Monoclonal
Clone TY25
Staining of mouse B7-DC transfected cells with 0.25 ug PE Rat IgG2a isotype control (open histogram) or 0.06 ug PE anti-mouse B7-DC (TY25, colored histogram). Total viable cells were used for analysis.

Anti-PDCD1LG2 / CD273 / PD-L2 Antibody (clone 1C9) - LS-C340019 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDCD1LG2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PDCD1LG2.
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