| Gene Symbol |
SNRPA
|
| Entrez Gene |
6626
|
| Alt Symbol |
Mud1, U1-A, U1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small nuclear ribonucleoprotein polypeptide A
|
| Other Description |
U1 small nuclear RNP-specific A|U1 small nuclear ribonucleoprotein A|U1 snRNP A|U1 snRNP-specific protein A
|
| Swissprots |
P09012
|
| Accessions |
AAA61245 EAW56995 EAW56996 P09012 AK293140 BAG56688 AK313182 BAG35999 BC000405 AAH00405 BC008290 AAH08290 BQ002918 CN286572 X06347 CAA29653 NM_004596 NP_004587
|
| Function |
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. {ECO:0000269|PubMed:9848648}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Spliceosome
|
![Western Blot: U1A Overexpression Lysate (Adult Normal) [NBL1-16285] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for U1A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9133_U1A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16285-img0003.jpg)