Gene Symbol | SNRPA |
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Entrez Gene | 6626 |
Alt Symbol | Mud1, U1-A, U1A |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein polypeptide A |
Other Description | U1 small nuclear RNP-specific A|U1 small nuclear ribonucleoprotein A|U1 snRNP A|U1 snRNP-specific protein A |
Swissprots | P09012 |
Accessions | AAA61245 EAW56995 EAW56996 P09012 AK293140 BAG56688 AK313182 BAG35999 BC000405 AAH00405 BC008290 AAH08290 BQ002918 CN286572 X06347 CAA29653 NM_004596 NP_004587 |
Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. {ECO:0000269|PubMed:9848648}. |
Subcellular Location | Nucleus. |
Top Pathways | Spliceosome |
Human U1A full length protein - ab132467 from Abcam
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Human U1A peptide - ab41553 from Abcam
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SNRPA / U1A Antibody Blocking Peptide - LS-E3567 from LifeSpan Bioscience
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SNRPA / U1A Antibody Blocking Peptide - LS-E14808 from LifeSpan Bioscience
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SNRPA / U1A Antibody Blocking Peptide - LS-E14809 from LifeSpan Bioscience
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Recombinant Human U1A Protein - H00006626-P01 from Novus Biologicals
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SNRPA-Antibody-Center-Blocking-Peptide - BP14764c from Abgent, a WuXi AppTec company
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Human SNRPA protein - orb169318 from Biorbyt
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Human SNRPA protein - orb245057 from Biorbyt
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SNRPA Blocking Peptide - 33R-6281 from Fitzgerald
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SNRPA1 protein (His tag) - 80R-2103 from Fitzgerald
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U1 snRNP protein A - H00006626-P01-10 from Acris Antibodies
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U1 snRNP protein A - H00006626-P01-25 from Acris Antibodies
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U1 snRNP protein A - P255-3 from Acris Antibodies
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Small Nuclear Ribonucleoprotein Polypeptide A, Human Recombinant - 228-12836-1 from RayBiotech
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Recombinant Human Small Nuclear Ribonucleoprotein Polypeptide A - 228-12836-2 from RayBiotech
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Recombinant Human Small Nuclear Ribonucleoprotein Polypeptide A - 228-12836-3 from RayBiotech
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SNRPA fusion protein - ag0283 from Proteintech Group
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Recombinant Human SNRPA1 protein - BP002061-PRO-1015 from Syd Labs
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Recombinant human U1 small nuclear ribonucleoprotein A protein - CSB-EP009744h CSB-BP009744h CSB-MP009744h from Cusabio
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Recombinant Human U1 small nuclear ribonucleoprotein A(SNRPA),partial - CSB-RP009744h from Cusabio
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Recombinant Human U1 small nuclear ribonucleoprotein A(SNRPA) - CSB-YP022327HU CSB-EP022327HU CSB-BP022327HU CSB-MP022327HU from Cusabio
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U1 small nuclear ribonucleoprotein A - RPC141330 from Biomatik
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Small Nuclear Ribonucleoprotein Polypeptide A Protein (Recombinant) - abx263457 from Abbexa
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Small Nuclear Ribonucleoprotein Polypeptide A Protein (Recombinant) - abx262968 from Abbexa
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