Gene Symbol | SNRPA |
---|---|
Entrez Gene | 6626 |
Alt Symbol | Mud1, U1-A, U1A |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein polypeptide A |
Other Description | U1 small nuclear RNP-specific A|U1 small nuclear ribonucleoprotein A|U1 snRNP A|U1 snRNP-specific protein A |
Swissprots | P09012 |
Accessions | AAA61245 EAW56995 EAW56996 P09012 AK293140 BAG56688 AK313182 BAG35999 BC000405 AAH00405 BC008290 AAH08290 BQ002918 CN286572 X06347 CAA29653 NM_004596 NP_004587 |
Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. {ECO:0000269|PubMed:9848648}. |
Subcellular Location | Nucleus. |
Top Pathways | Spliceosome |