FOXO4

Gene Symbol FOXO4
Entrez Gene 4303
Alt Symbol AFX, AFX1, MLLT7
Species Human
Gene Type protein-coding
Description forkhead box O4
Other Description fork head domain transcription factor AFX1|forkhead box protein O4|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
Swissprots Q8TDK9 O43821 B7WPJ7 P98177 Q13720 Q3KPF1
Accessions CAA72156 EAX05321 EAX05322 P98177 AF384029 AAL85197 AK300142 BAG61928 AW292413 BC026735 BC106761 AAI06762 BP349083 U10072 AAA82171 X93996 CAA63819 XM_011530957 XP_011529259 NM_001170931 NP_001164402 NM_005938 NP_005929
Function Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}.
Subcellular Location Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

Mouse/Human FOXO4 / AFX1 ELISA Kit (Cell-Based ELISA) - LS-F3307 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Mouse/Human/Rat FOXO4 / AFX1 ELISA Kit (DNA-Binding ELISA) - LS-F758 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate

Mouse/Human Phospho-FOXO4 / AFX1 (Ser197) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1513 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human FOXO4 / AFX1 ELISA Kit (Cell-Based ELISA) - LS-F2000 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Mouse/Human Phospho-FOXO4 / AFX1 (Thr451) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1417 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human Phospho-FOXO4 / AFX1 (Ser262) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1661 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Forkhead Box Protein O4, FOXO4, Human, ELISA Kit - E-EL-H1102 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Forkhead Box Protein O4, FOXO4, Rabbit, ELISA Kit - E-EL-RB1830 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Forkhead Box Protein O4, FOXO4, Chicken, ELISA Kit - E-EL-Ch0558 from ARP American Research Products

Category ELISA Kit
Prices $504.00
Sizes 96 t

Forkhead Box Protein O4, FOXO4, Porcine, ELISA Kit - E-EL-P1375 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Forkhead Box Protein O4, FOXO4, Sheep, ELISA Kit - E-EL-S0547 from ARP American Research Products

Category ELISA Kit
Prices $648.00
Sizes 96 t

Forkhead Box Protein O4, FOXO4, Monkey, ELISA Kit - E-EL-MK1496 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Custom Human FOXO4 ELISA - ELH-FOXO4 from RayBiotech

Category ELISA Kit
Prices $615.00, $1,107.00, $2,460.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit

FOXO4 Colorimetric Cell-Based ELISA Kit - CB5276 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

AFX Colorimetric Cell-Based ELISA - CB6148 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

FOXO4 (Phospho-Thr451) Colorimetric Cell-Based ELISA Kit - CBP1449 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

FOXO4 (Phospho-Ser197) Colorimetric Cell-Based ELISA Kit - CBP1559 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

FOXO4 (Phospho-Ser262) Colorimetric Cell-Based ELISA Kit - CBP1722 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

AFX TFact™ DNA-Binding ELISA - TFE-7060 from Assay Biotechnology

Category ELISA Kit
Prices $495.00, $990.00, $1,485.00
Sizes 1 kit, 2 kits, 3 kits

Human FOXO4(Forkhead Box Protein O4) ELISA Kit - E-EL-H1102 from Elabscience

Category ELISA Kit
Sensitivity 0.19 ng/mL
Range 0.31—20 ng/mL

Forkhead box O3A, FOXO3A, ELISA Kit - MBS9306740 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

forkhead box O4, FOXO4, ELISA Kit - MBS9301898 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

forkhead box O4, FOXO4, ELISA Kit - MBS9304315 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FOXO4, ELISA Kit - MBS2508807 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.188ng/mL
Range 0.313-20ng/mL

FOXO4, ELISA Kit - MBS2506308 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 75pg/mL
Range 125-8000pg/mL
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