| Gene Symbol | FOXO4 |
|---|---|
| Entrez Gene | 4303 |
| Alt Symbol | AFX, AFX1, MLLT7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | forkhead box O4 |
| Other Description | fork head domain transcription factor AFX1|forkhead box protein O4|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 |
| Swissprots | Q8TDK9 O43821 B7WPJ7 P98177 Q13720 Q3KPF1 |
| Accessions | CAA72156 EAX05321 EAX05322 P98177 AF384029 AAL85197 AK300142 BAG61928 AW292413 BC026735 BC106761 AAI06762 BP349083 U10072 AAA82171 X93996 CAA63819 XM_011530957 XP_011529259 NM_001170931 NP_001164402 NM_005938 NP_005929 |
| Function | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm. |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas. |
FOXO4 / AFX1 Antibody Blocking Peptide - LS-E10560 from LifeSpan Bioscience
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FOXO4 / AFX1 Antibody Blocking Peptide - LS-E30949 from LifeSpan Bioscience
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FOXO4 / AFX1 Antibody Blocking Peptide - LS-E30950 from LifeSpan Bioscience
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FOXO4 / AFX1 Antibody Blocking Peptide - LS-E11222 from LifeSpan Bioscience
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FOXO4 / AFX1 Antibody Blocking Peptide - LS-E13935 from LifeSpan Bioscience
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FOXO4 / AFX1 Antibody Blocking Peptide - LS-E26314 from LifeSpan Bioscience
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FOXO4 Blocking Peptide - NBP1-77175PEP from Novus Biologicals
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FOXO4 Blocking Peptide - NBP1-77174PEP from Novus Biologicals
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FOXO4 blocking peptide - GTX89101-PEP from GeneTex
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Goat anti FOXO4 antibody Immunizing peptide - orb16392 from Biorbyt
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AFX Blocking Peptide - 33R-10745 from Fitzgerald
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AFX Blocking Peptide - 33R-10484 from Fitzgerald
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FOXO4 (phospho-Ser197) Blocking Peptide - abx062937 from Abbexa
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FOXO4 (phospho-Thr451) Blocking Peptide - abx062938 from Abbexa
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FOXO4 Blocking Peptide - abx062939 from Abbexa
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FOXO4 Peptide - AC21-1149-P from Abcore
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FOXO4 / AFX1 / MLLT7 control peptide - AP26177CP-N from Acris Antibodies
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FOXO4 / AFX1 / MLLT7 control peptide - AP26178CP-N from Acris Antibodies
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FOXO4 Peptide - 5815P from ProSci
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FOXO4 Peptide - 5817P from ProSci
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FOXO4 Peptide - 45-623P from ProSci
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FOXO4 fusion protein - ag17035 from Proteintech Group
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FOXO4 fusion protein - ag16169 from Proteintech Group
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AFX (Phospho-Ser197) Antibody Blocking Peptide - GWB-755000 from Genway Biotech
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FOXO4 (pS197) Blocking Peptide - CBP1743 from Cohesion Biosciences
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