FOXO4

Gene Symbol FOXO4
Entrez Gene 4303
Alt Symbol AFX, AFX1, MLLT7
Species Human
Gene Type protein-coding
Description forkhead box O4
Other Description fork head domain transcription factor AFX1|forkhead box protein O4|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
Swissprots Q8TDK9 O43821 B7WPJ7 P98177 Q13720 Q3KPF1
Accessions CAA72156 EAX05321 EAX05322 P98177 AF384029 AAL85197 AK300142 BAG61928 AW292413 BC026735 BC106761 AAI06762 BP349083 U10072 AAA82171 X93996 CAA63819 XM_011530957 XP_011529259 NM_001170931 NP_001164402 NM_005938 NP_005929
Function Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}.
Subcellular Location Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

FOXO4-Over-expression-Lysate - LY10589a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag FOXO4 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FOXO4 gene (Lane 2, Cat. #LY10589a).

FOXO4 overexpression lysate - LY401798 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

FOXO4 293 Cell Lysate - 401605 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

FOXO4 Overexpression Lysate (Native) - NBL1-10815 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: FOXO4 Overexpression Lysate (Adult Normal) [NBL1-10815] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FOXO4.

FOXO4 Over-expression Lysate Product - GWB-859CB0 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human FOXO4 Knockdown Stable Cell Line - CSC-DC005875 from Creative biogene

Category Cell Line
Species Human
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