FOXO4

Gene Symbol FOXO4
Entrez Gene 4303
Alt Symbol AFX, AFX1, MLLT7
Species Human
Gene Type protein-coding
Description forkhead box O4
Other Description fork head domain transcription factor AFX1|forkhead box protein O4|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
Swissprots Q8TDK9 O43821 B7WPJ7 P98177 Q13720 Q3KPF1
Accessions CAA72156 EAX05321 EAX05322 P98177 AF384029 AAL85197 AK300142 BAG61928 AW292413 BC026735 BC106761 AAI06762 BP349083 U10072 AAA82171 X93996 CAA63819 XM_011530957 XP_011529259 NM_001170931 NP_001164402 NM_005938 NP_005929
Function Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}.
Subcellular Location Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

AFX1 CRISPR/Cas9 KO Plasmid (h) - sc-402408 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFX1 HDR Plasmid (h) - sc-402408-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFX1 Double Nickase Plasmid (h) - sc-402408-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFX1 Double Nickase Plasmid (h2) - sc-402408-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFX1 CRISPR Activation Plasmid (h) - sc-402408-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFX1 CRISPR Activation Plasmid (h2) - sc-402408-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFX1 Lentiviral Activation Particles (h) - sc-402408-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFX1 Lentiviral Activation Particles (h2) - sc-402408-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AFX1 siRNA (h) - sc-29650 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AFX1 shRNA Plasmid (h) - sc-29650-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AFX1 shRNA (h) Lentiviral Particles - sc-29650-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FOXO4 RNAi - H00004303-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU075731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8912 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8912 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12675 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12675

FOXO4 siRNA (Human) - CRH2921 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FOXO4 - MBS8225247 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FOXO4 (NM_005938.3) - SHH296777 from Creative biogene

Category siRNA
Species Reactivities Human

Human FOXO4 siRNA - orb263423 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FOXO4 shRNA Plasmid (Human) - CHH2921 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FOXO4 miRNA 3'UTR clone - MiUTR3H-02507 from Creative biogene

Species Reactivities Human
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