PPM1B

Gene Symbol PPM1B
Entrez Gene 5495
Alt Symbol PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
Species Human
Gene Type protein-coding
Description protein phosphatase, Mg2+/Mn2+ dependent, 1B
Other Description Ser/Thr protein phosphatase type 2C beta 2 isoform|protein phosphatase 1B|protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform|protein phosphatase 2C-like protein
Swissprots Q461Q2 Q96ER6 Q658R4 Q4J6C2 Q9HAY8 O75688 Q4J6C1
Accessions AAX88954 EAX00280 EAX00281 EAX00282 EAX00283 O75688 AA742374 AA769851 AF136972 AAG49433 AF294792 AAG02232 AJ005801 CAA06704 AJ271832 CAC27992 AJ271835 CAC27993 AK056009 BAG51602 AK291214 BAF83903 AL833035 CAH56319 BC012002 AAH12002 BC064381 AAH64381 BF979498 BQ773881 DA128532 DQ023508 AAY89639 DQ023509 AAY89640 DQ023510 AAY89641 DQ023511 AAY89642 HQ448711 ADQ33189 XM_011532936 XP_011531238 NM_001033557 NP_001028729 NM_002706 NP_002697 NM_177968 NP_808907 NM_177969 NP_808908 NM_001033556
Function Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.
Tissue Specificity Highly expressed in heart and skeletal muscle.
Top Pathways MAPK signaling pathway

PP2Cβ (P-13) - sc-50855 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PP2Cβ (P-13): sc-50855. Western blot analysis of PP2Cβ expression in non-transfected 293T: sc-117752 (A), human PP2Cβ transfected 293T: sc-116891 (B) and HeLa (C) whole cell lysates.

PP2Cβ (Y-14) - sc-50858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PP2Cβ (k1B1) - sc-134219 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PP2Cβ (k1B1): sc-134219. Western blot analysis of PP2Cβ expression in MCF7 whole cell lysate.

Anti-PPM1B antibody - ab60238 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab60238 at 1/50 dilution, staining PPM1B in human breast carcinoma by Immunohistochemistry, Formalin fixed, Paraffin embedded tissue, followed by peroxidase conjugated secondary antibody and AEC staining.

Anti-PPM1B antibody - ab70804 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PPM1B antibody (ab70804) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-PPM1B antibody - ab60242 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab60242 at 1/50 dilution, staining PPM1B in human hepatocarcinoma by Immunohistochemistry, Formalin fixed, Paraffin embedded tissue, followed by peroxidase conjugated secondary antibody and AEC staining.

Anti-PPM1B antibody - ab58146 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab58146 PPM1B antibody at 1ug/ml.

Anti-PPM1B antibody [3C9] - ab139159 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C9
All lanes : Anti-PPM1B antibody [3C9] (ab139159) at 1/1000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY PPM1B cDNALysates/proteins at 5 µg per lane.

Anti-PPM1B antibody [3G9] - ab119098 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G9
All lanes : Anti-PPM1B antibody [3G9] (ab119098) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY PPM1B cDNALysates/proteins at 5 µg per lane.developed using the ECL technique

Anti-PPM1B Antibody (clone 3E8) - LS-C172765 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E8
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-PPM1B mouse monoclonal antibody.

Anti-PPM1B Antibody (clone 3A10) - LS-C172950 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3A10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPM1B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPM1B.

Anti-PPM1B Antibody (clone 3E10) - LS-C172951 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3E10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPM1B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPM1B.

Anti-PPM1B Antibody (clone 3C9) - LS-C172954 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C9
Anti-PPM1B mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PPM1B.

Anti-PPM1B Antibody (clone 1A3-2A4) - LS-C197966 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A3-2A4
Immunofluorescence of monoclonal antibody to PPM1B on HeLa cell. [antibody concentration 10 ug/ml]

Anti-PPM1B Antibody (clone 3F2) - LS-C172953 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F2
Western blot of extracts (35 ug) from 9 different cell lines by using anti-PPM1B monoclonal antibody.

Anti-PPM1B Antibody (C-Terminus) - LS-C91551 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-PPM1B Antibody (aa1-479) - LS-C131253 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPM1B Antibody (aa288-479, clone K1B1) - LS-C93786 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone K1B1
Cell lysates of MCF7 (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human PPM1B (1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Anti-PPM1B Antibody (aa35-84) - LS-C112122 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PPM1B antibody LS-C112122 Western blot of Jurkat lysate.

Anti-PPM1B Antibody (C-Terminus) - LS-C287727 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1B Antibody (aa400-450) - LS-C287726 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPM1B Antibody (clone 2D9) - LS-C337383 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPM1B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPM1B.

Anti-PPM1B Antibody (clone 3G9) - LS-C337438 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPM1B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPM1B.

Anti-PPM1B Antibody (clone 2H5) - LS-C172918 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPM1B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPM1B.

Anti-PPM1B Antibody (clone 3C2) - LS-C172919 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PPM1B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PPM1B.
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