| Gene Symbol |
PPM1B
|
| Entrez Gene |
5495
|
| Alt Symbol |
PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase, Mg2+/Mn2+ dependent, 1B
|
| Other Description |
Ser/Thr protein phosphatase type 2C beta 2 isoform|protein phosphatase 1B|protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform|protein phosphatase 2C-like protein
|
| Swissprots |
Q461Q2 Q96ER6 Q658R4 Q4J6C2 Q9HAY8 O75688 Q4J6C1
|
| Accessions |
AAX88954 EAX00280 EAX00281 EAX00282 EAX00283 O75688 AA742374 AA769851 AF136972 AAG49433 AF294792 AAG02232 AJ005801 CAA06704 AJ271832 CAC27992 AJ271835 CAC27993 AK056009 BAG51602 AK291214 BAF83903 AL833035 CAH56319 BC012002 AAH12002 BC064381 AAH64381 BF979498 BQ773881 DA128532 DQ023508 AAY89639 DQ023509 AAY89640 DQ023510 AAY89641 DQ023511 AAY89642 HQ448711 ADQ33189 XM_011532936 XP_011531238 NM_001033557 NP_001028729 NM_002706 NP_002697 NM_177968 NP_808907 NM_177969 NP_808908 NM_001033556
|
| Function |
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in heart and skeletal muscle.
|
| Top Pathways |
MAPK signaling pathway
|