PPM1B

Gene Symbol	PPM1B
Entrez Gene	5495
Alt Symbol	PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
Species	Human
Gene Type	protein-coding
Description	protein phosphatase, Mg2+/Mn2+ dependent, 1B
Other Description	Ser/Thr protein phosphatase type 2C beta 2 isoform|protein phosphatase 1B|protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform|protein phosphatase 2C-like protein
Swissprots	Q461Q2 Q96ER6 Q658R4 Q4J6C2 Q9HAY8 O75688 Q4J6C1
Accessions	AAX88954 EAX00280 EAX00281 EAX00282 EAX00283 O75688 AA742374 AA769851 AF136972 AAG49433 AF294792 AAG02232 AJ005801 CAA06704 AJ271832 CAC27992 AJ271835 CAC27993 AK056009 BAG51602 AK291214 BAF83903 AL833035 CAH56319 BC012002 AAH12002 BC064381 AAH64381 BF979498 BQ773881 DA128532 DQ023508 AAY89639 DQ023509 AAY89640 DQ023510 AAY89641 DQ023511 AAY89642 HQ448711 ADQ33189 XM_011532936 XP_011531238 NM_001033557 NP_001028729 NM_002706 NP_002697 NM_177968 NP_808907 NM_177969 NP_808908 NM_001033556
Function	Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.
Tissue Specificity	Highly expressed in heart and skeletal muscle.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PP2Cβ siRNA (h) - sc-61387 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PP2Cβ shRNA Plasmid (h) - sc-61387-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PP2Cβ shRNA (h) Lentiviral Particles - sc-61387-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PP2C beta/PPM1B RNAi - H00005495-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PP2C beta/PPM1B RNAi - H00005495-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PP2C beta/PPM1B RNAi - H00005495-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PP2C beta/PPM1B RNAi - H00005495-R09 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PP2C beta/PPM1B RNAi - H00005495-R10 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU069851 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® Human Phosphatase - SIHP0480 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1014 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0478 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1017 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1018 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1015 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0479 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1013 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP1016 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17241 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17241 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11120 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11120

PPM1B siRNA (Human) - CRH3681 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PP2C beta/PPM1B RNAi - H00005495-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PPM1B (NM_177969.2) - SHH380796 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PPM1B(NM_001033557.1) - SHR105338 from Creative biogene Category siRNA Species Reactivities Human

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