PPM1B

Gene Symbol	PPM1B
Entrez Gene	5495
Alt Symbol	PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
Species	Human
Gene Type	protein-coding
Description	protein phosphatase, Mg2+/Mn2+ dependent, 1B
Other Description	Ser/Thr protein phosphatase type 2C beta 2 isoform|protein phosphatase 1B|protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform|protein phosphatase 2C-like protein
Swissprots	Q461Q2 Q96ER6 Q658R4 Q4J6C2 Q9HAY8 O75688 Q4J6C1
Accessions	AAX88954 EAX00280 EAX00281 EAX00282 EAX00283 O75688 AA742374 AA769851 AF136972 AAG49433 AF294792 AAG02232 AJ005801 CAA06704 AJ271832 CAC27992 AJ271835 CAC27993 AK056009 BAG51602 AK291214 BAF83903 AL833035 CAH56319 BC012002 AAH12002 BC064381 AAH64381 BF979498 BQ773881 DA128532 DQ023508 AAY89639 DQ023509 AAY89640 DQ023510 AAY89641 DQ023511 AAY89642 HQ448711 ADQ33189 XM_011532936 XP_011531238 NM_001033557 NP_001028729 NM_002706 NP_002697 NM_177968 NP_808907 NM_177969 NP_808908 NM_001033556
Function	Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269|PubMed:18930133, ECO:0000269|PubMed:22750291}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.
Tissue Specificity	Highly expressed in heart and skeletal muscle.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PPM1B full length protein - ab159168 from Abcam Category Protein Source Wheat germ Species Human

PPM1B Antibody Blocking Peptide - LS-E21104 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PP2C beta/PPM1B Protein - H00005495-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PP2C beta/PPM1B Peptide - P3313 from Novus Biologicals Category Peptide Species Human

PPM1B-Antibody-Center-Blocking-Peptide - BP8467b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPM1B-Antibody-Center-L76-Blocking-Peptide - BP8467a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PPM1B protein - orb246413 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PPM1B Blocking Peptide - 33R-2480 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Protein phosphatase 1B / PPM1B - H00005495-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Protein phosphatase 1B / PPM1B - H00005495-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPM1B fusion protein - Ag3871 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PPM1B, GST-tagged - PPM1B-1894H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein phosphatase 1B(PPM1B) - CSB-EP018490HU CSB-BP018490HU CSB-MP018490HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Protein phosphatase 1B(PPM1B) - CSB-YP018490HU from Cusabio Category Protein Source Yeast Species Human

Protein phosphatase 1B / PPM1B (transcript variant 3) - TP309425 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Protein phosphatase 1B / PPM1B (transcript variant 1) - TP312918 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Protein phosphatase 1B / PPM1B (transcript variant 2) - TP322782 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PP2C beta/PPM1B Recombinant Protein Antigen - NBP1-87250PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PPM1B Peptide, Human - M34GP12213H from Creative Peptides Category Peptide Source Synthetic. Species Human

PPM1B Recombinant Protein (OPCA01793) - OPCA01793 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Protein phosphatase 1B - AP70656 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

phosphatase 1B, Recombinant Protein - MBS9420558 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Phosphatase 1B, Recombinant Protein - MBS1173136 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00, $1,260.00, $1,480.00, $1,480.00, $2,060.00, $2,525.00, $2,525.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

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