CHRDL1

Gene Symbol CHRDL1
Entrez Gene 91851
Alt Symbol CHL, MGC1, MGCN, NRLN1, VOPT, dA141H5.1
Species Human
Gene Type protein-coding
Description chordin-like 1
Other Description chordin-like protein 1|neuralin 1|neuralin-1|neurogenesin-1|ventroptin
Swissprots Q539E4 B1AKD0 Q9Y3H7 Q9BU40 E9PGS5 D3DUY6 B4DMP3
Accessions EAX02655 EAX02656 EAX02657 Q9BU40 AA057564 AB209548 BAD92785 AK092245 BAG52508 AK293106 BAF85795 AK297563 BAG59955 AK312270 AY608914 AAU25841 BC002909 AAH02909 BP377491 DC404314 XM_005262221 XP_005262278 XM_005262222 XP_005262279 XM_005262223 XP_005262280 XM_005262224 XP_005262281 NM_001143981 NP_001137453 NM_001143982 NP_001137454 NM_001143983 NP_001137455 NM_145234 NP_660277
Function Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. {ECO:0000250, ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}.
Subcellular Location Secreted {ECO:0000305}.
Tissue Specificity Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes. {ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}.

CHRDL1 (E-14) - sc-240232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CHRDL1 (SS-6) - sc-100333 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
CHRDL1 (SS-6): sc-100333. Western blot analysis of CHRDL1 expression in HeLa nuclear extract.

Anti-CHRDL1 antibody - ab103369 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab103369 stained DU145 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab103369 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-CHRDL1 antibody - ab107008 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CHRDL1 antibody (ab107008) at 1/100 dilution + 293 cell line lysate at 35 µg

Anti-CHRDL1 antibody - ab57933 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-CHRDL1 antibody [3H1-F6-A10] - ab131189 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H1-F6-A10
Anti-CHRDL1 antibody [3H1-F6-A10] (ab131189) at 1/1000 dilution + Rat kidney tissue lysate

Anti-CHRDL1 Antibody (aa347-457, clone 10B2236, Azide-free) - LS-C183516 from LifeSpan Bioscience

Prices $590.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10B2236

Anti-CHRDL1 Antibody (aa5-35, Biotin) - LS-C233819 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRDL1 Antibody (aa5-35, APC) - LS-C233818 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRDL1 Antibody (aa5-35, AP) - LS-C233817 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRDL1 Antibody (aa5-35, PE) - LS-C233821 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRDL1 Antibody (aa5-35, FITC) - LS-C233820 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRDL1 Antibody (aa347-457) - LS-C307790 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CHRDL1 Antibody (aa5-35, Azide-free, HRP) - LS-C249670 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRDL1 Antibody - LS-C307788 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CHRDL1 Antibody - LS-C309910 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHRDL1 Antibody (aa5-35) - LS-C320368 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CHRDL1 Antibody - LS-C342015 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CHRDL1 Antibody (aa5-35) - LS-C168749 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CHRDL1 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Chordin-like 1/CHRDL1 Antibody (263737) - MAB1808 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 263737

Chordin-like 1/CHRDL1 Antibody - AF1808 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

Chordin-like 1/CHRDL1 Antibody - NBP1-84486 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Chordin-like 1/CHRDL1 Antibody [NBP1-84486] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

Chordin-like 1/CHRDL1 Antibody - NBP1-84485 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CHRDL1 Antibody [NBP1-84485] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10 | Lane 2: Negative control (vector only transfected HEK293T lysate) | Lane 3: Over-expression Lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells.

Chordin-like 1/CHRDL1 Antibody - H00091851-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CHRDL1 Antibody [H00091851-D01P] - Western Blot analysis of CHRDL1 expression in mouse kidney.

Chordin-like 1/CHRDL1 Antibody - H00091851-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Chordin-like 1/CHRDL1 Antibody [H00091851-B01] - analysis of CHRDL1 expression in transfected 293T cell line by CHRDL1 MaxPab polyclonal antibody (B01). Lane 1: CHRDL1 transfected lysate (51.20 KDa). Lane 2: Non-transfected lysate.
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