FOLR1

Gene Symbol	FOLR1
Entrez Gene	2348
Alt Symbol	FBP, FOLR
Species	Human
Gene Type	protein-coding
Description	folate receptor 1 (adult)
Other Description	FR-alpha|KB cells FBP|adult folate-binding protein|folate binding protein|folate receptor alpha|folate receptor, adult|ovarian tumor-associated antigen MOv18
Swissprots	Q6LC90 Q53EW2 Q9UCT2 Q6FGT8 P15328
Accessions	AAB05827 EAW74848 EAW74849 EAW74850 EAW74851 EAW74852 P15328 AF000381 AAB81938 AK223527 BAD97247 BC002947 AAH02947 BT007158 AAP35822 CA450368 CR542019 CAG46816 DQ892744 ABM83670 DQ895990 ABM86943 J05013 AAA35823 M25317 AAA74896 M28099 AAA35822 M35069 AAA35824 S73474 AAB31702 S73490 AAB31700 U78793 AAB39751 U78794 AAB39752 X62753 CAA44610 NM_000802 NP_000793 NM_016724 NP_057936 NM_016725 NP_057937 NM_016729 NP_057941 NM_016730
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. {ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane {ECO:0000250}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Tissue Specificity	Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:2768245, ECO:0000269|PubMed:9063895}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FOLR1 / Folate Receptor Alpha ELISA Kit (Sandwich ELISA) - LS-F2910 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 46.9 pg/ml Range 94-6000 pg/ml

Mouse FOLR1 / Folate Receptor Alpha ELISA Kit (Sandwich ELISA) - LS-F2911 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 94-6000 pg/ml

Human FOLR1 / Folate Receptor Alpha ELISA Kit (Sandwich ELISA) - LS-F6460 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 5.8 pg/ml Range 94-6000 pg/ml

Human FOLR1 / Folate Receptor Alpha ELISA Kit (Custom ELISA) - LS-F344 from LifeSpan Bioscience Category ELISA Kit Prices $670.00, $1,190.00, $2,570.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity To be determined Range 94-6000 pg/ml

Human FOLR1 / Folate Receptor Alpha ELISA Kit (Sandwich ELISA) - LS-F701 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 94-6000 pg/ml

Mouse FOLR1 / Folate Receptor Alpha ELISA Kit (Sandwich ELISA) - LS-F8728 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 3.4 pg/ml Range 94-6000 pg/ml

Human FOLR1 / Folate Receptor Alpha ELISA Kit - RAB0659 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

Human FOLR1 Quantikine ELISA Kit - DFLR10 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 14.9 pg/mL Range 46.9 - 3,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva, Urine, Human Milk)

Human FOLR1 DuoSet ELISA - DY5646 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 93.80 - 6,000 pg/mL

Quantikine Immunoassay Control Set 724 for Human FOLR1 - QC92 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

FOLR1 ELISA Kit (Human) : 96 Wells (OKAG00225) - OKAG00225 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 94 pg/mL Range 94-6,000 pg/mL

Human FOLR1 ELISA Kit - orb180623 from Biorbyt Category ELISA Kit Prices $570.00 Sizes 96 well Sensitivity < 10 pg/ml Range 46.9 pg/ml-3000 pg/ml

Human FOLR1 ELISA Kit - abx151579 from Abbexa Category ELISA Kit Sensitivity 5.8 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Folate receptor alpha, FOLR1, Human, ELISA Kit - E1599h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 15.6-1000 pg/mL

Custom Human FOLR1 ELISA - ELH-FOLR1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

FR alpha, ELISA Kit - MBS824539 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 46.9 pg/ml - 3000 pg/ml

FOLR1 (Human) OmniKine™ ELISA Kit - OK-0330 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range 94-6000 pg/ml

Human FOLR1 ELISA Kit - DEIA2981 from Creative Diagnostics Category ELISA Kit Sensitivity Thirty assays were evaluated and the minimum detectable dose (MDD) of FOLR1 ranged from 1.67-14.9 pg/mL. The mean MDD was 5.54 pg/mL. The MDD was determined by adding two standard deviations to the mean optical density value of twenty zero standard rep

Human FOLR1 ELISA Kit - DEIA3478 from Creative Diagnostics Category ELISA Kit Sensitivity The antigens listed below were tested at 50 ng/mL.

folate receptor 1 (adult) , ELISA Kit - MBS941430 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 31.25 pg/ml. Range 125 pg/ml -8000 pg/ml.

Folate Receptor 1, Adult, ELISA Kit - MBS086022 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Folate Receptor 1, Adult, ELISA Kit - MBS081934 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Folate Receptor 1, Adult, ELISA Kit - MBS063519 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Folate Receptor 1, Adult, ELISA Kit - MBS090656 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Folate Receptor 1, Adult, ELISA Kit - MBS097569 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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