FOLR1

Gene Symbol	FOLR1
Entrez Gene	2348
Alt Symbol	FBP, FOLR
Species	Human
Gene Type	protein-coding
Description	folate receptor 1 (adult)
Other Description	FR-alpha|KB cells FBP|adult folate-binding protein|folate binding protein|folate receptor alpha|folate receptor, adult|ovarian tumor-associated antigen MOv18
Swissprots	Q6LC90 Q53EW2 Q9UCT2 Q6FGT8 P15328
Accessions	AAB05827 EAW74848 EAW74849 EAW74850 EAW74851 EAW74852 P15328 AF000381 AAB81938 AK223527 BAD97247 BC002947 AAH02947 BT007158 AAP35822 CA450368 CR542019 CAG46816 DQ892744 ABM83670 DQ895990 ABM86943 J05013 AAA35823 M25317 AAA74896 M28099 AAA35822 M35069 AAA35824 S73474 AAB31702 S73490 AAB31700 U78793 AAB39751 U78794 AAB39752 X62753 CAA44610 NM_000802 NP_000793 NM_016724 NP_057936 NM_016725 NP_057937 NM_016729 NP_057941 NM_016730
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. {ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane {ECO:0000250}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Tissue Specificity	Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:2768245, ECO:0000269|PubMed:9063895}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

α-FR (F-15) - sc-16386 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

FR (FL-257) - sc-28997 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

FR (N-20) - sc-16387 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

FR (C-17) - sc-16388 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Folate Binding Protein antibody - ab67422 from Abcam Prices $384.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Folate Binding Protein antibody - ab137347 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Folate Binding Protein antibody - ab136074 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Folate Binding Protein antibody [EPR4708(2)] - ab125030 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4708(2)

Anti-Folate Binding Protein antibody [LK26] - ab3361 from Abcam Prices $385.00 Sizes 500 µl Host Mouse Clonality Monoclonal Clone LK26

Anti-Folate Binding Protein antibody - N-terminal - ab139000 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody - LS-C129128 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody - LS-C129129 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody - LS-C129130 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa25-233) - LS-C125620 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa25-233, APC) - LS-C129132 from LifeSpan Bioscience Prices $590.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa33-68, Biotin) - LS-C214276 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa33-68, APC) - LS-C214275 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa33-68, AP) - LS-C214273 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa33-68, FITC) - LS-C214277 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa33-68, Azide-free, HRP) - LS-C214280 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa33-68, PE) - LS-C214282 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa31-80) - LS-C291951 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa25-234, Biotin) - LS-C298060 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa41-90) - LS-C119975 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-FOLR1 / Folate Receptor Alpha Antibody (aa26-229, Biotin) - LS-C299341 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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