FOLR1
| Gene Symbol | FOLR1 |
|---|---|
| Entrez Gene | 2348 |
| Alt Symbol | FBP, FOLR |
| Species | Human |
| Gene Type | protein-coding |
| Description | folate receptor 1 (adult) |
| Other Description | FR-alpha|KB cells FBP|adult folate-binding protein|folate binding protein|folate receptor alpha|folate receptor, adult|ovarian tumor-associated antigen MOv18 |
| Swissprots | Q6LC90 Q53EW2 Q9UCT2 Q6FGT8 P15328 |
| Accessions | AAB05827 EAW74848 EAW74849 EAW74850 EAW74851 EAW74852 P15328 AF000381 AAB81938 AK223527 BAD97247 BC002947 AAH02947 BT007158 AAP35822 CA450368 CR542019 CAG46816 DQ892744 ABM83670 DQ895990 ABM86943 J05013 AAA35823 M25317 AAA74896 M28099 AAA35822 M35069 AAA35824 S73474 AAB31702 S73490 AAB31700 U78793 AAB39751 U78794 AAB39752 X62753 CAA44610 NM_000802 NP_000793 NM_016724 NP_057936 NM_016725 NP_057937 NM_016729 NP_057941 NM_016730 |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. {ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}. |
| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane {ECO:0000250}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. |
| Tissue Specificity | Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:2768245, ECO:0000269|PubMed:9063895}. |
| Top Pathways | Endocytosis |
α-FR CRISPR/Cas9 KO Plasmid (h) - sc-400909 from Santa Cruz Biotechnology
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α-FR HDR Plasmid (h) - sc-400909-HDR from Santa Cruz Biotechnology
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α-FR Double Nickase Plasmid (h) - sc-400909-NIC from Santa Cruz Biotechnology
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α-FR Double Nickase Plasmid (h2) - sc-400909-NIC-2 from Santa Cruz Biotechnology
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α-FR CRISPR Activation Plasmid (h) - sc-400909-ACT from Santa Cruz Biotechnology
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α-FR CRISPR Activation Plasmid (h2) - sc-400909-ACT-2 from Santa Cruz Biotechnology
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α-FR Lentiviral Activation Particles (h) - sc-400909-LAC from Santa Cruz Biotechnology
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α-FR Lentiviral Activation Particles (h2) - sc-400909-LAC-2 from Santa Cruz Biotechnology
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α-FR siRNA (h) - sc-39969 from Santa Cruz Biotechnology
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α-FR shRNA Plasmid (h) - sc-39969-SH from Santa Cruz Biotechnology
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α-FR shRNA (h) Lentiviral Particles - sc-39969-V from Santa Cruz Biotechnology
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FOLR1 RNAi - H00002348-R12 from Novus Biologicals
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FOLR1 RNAi - H00002348-R08 from Novus Biologicals
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FOLR1 RNAi - H00002348-R10 from Novus Biologicals
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FOLR1 RNAi - H00002348-R07 from Novus Biologicals
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FOLR1 RNAi - H00002348-R11 from Novus Biologicals
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MISSION® esiRNA - EHU071531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8867 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8867 from Sigma-Aldrich
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FOLR1 siRNA (Human) - CRH1641 from Cohesion Biosciences
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FOLR1 RNAi - H00002348-R09 from Novus Biologicals
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FOLR1 - MBS828938 from MyBioSource
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α-FR CRISPR/Cas9 KO Plasmid (h2) - sc-400909-KO-2 from Santa Cruz Biotechnology
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α-FR HDR Plasmid (h2) - sc-400909-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human FOLR1 (NM_000802.3) - SHH296265 from Creative biogene
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