FOLR1

Gene Symbol FOLR1
Entrez Gene 2348
Alt Symbol FBP, FOLR
Species Human
Gene Type protein-coding
Description folate receptor 1 (adult)
Other Description FR-alpha|KB cells FBP|adult folate-binding protein|folate binding protein|folate receptor alpha|folate receptor, adult|ovarian tumor-associated antigen MOv18
Swissprots Q6LC90 Q53EW2 Q9UCT2 Q6FGT8 P15328
Accessions AAB05827 EAW74848 EAW74849 EAW74850 EAW74851 EAW74852 P15328 AF000381 AAB81938 AK223527 BAD97247 BC002947 AAH02947 BT007158 AAP35822 CA450368 CR542019 CAG46816 DQ892744 ABM83670 DQ895990 ABM86943 J05013 AAA35823 M25317 AAA74896 M28099 AAA35822 M35069 AAA35824 S73474 AAB31702 S73490 AAB31700 U78793 AAB39751 U78794 AAB39752 X62753 CAA44610 NM_000802 NP_000793 NM_016724 NP_057936 NM_016725 NP_057937 NM_016729 NP_057941 NM_016730
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. {ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane {ECO:0000250}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Tissue Specificity Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:2768245, ECO:0000269|PubMed:9063895}.
Top Pathways Endocytosis

FOLR1 293T Cell Transient Overexpression Lysate(Denatured) - H00002348-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

FOLR1 293 Cell Lysate - 402253 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

FOLR1 Overexpression Lysate (Denatured) - H00002348-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
FOLR1 transfected lysate

FOLR1 Overexpression Lysate (Native) - NBP2-07006 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Folate Binding Protein Overexpression Lysate (Adult Normal) [NBP2-07006] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Folate Binding Protein.

FOLR1 Overexpression Lysate (Native) - NBP2-06995 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

FOLR1 Overexpression Lysate (Native) - NBL1-10790 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Folate Binding Protein Overexpression Lysate (Adult Normal) [NBL1-10790] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Folate Binding Protein.

FOLR1 Over-expression Lysate Product - GWB-33C12B from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Human FOLR1 / Folate receptor alpha HEK293 Cell Lysate (WB positive control) - 11241-H08HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

FOLR1 Overexpression Lysate (Native) - NBP2-11281 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Folate Binding Protein Overexpression Lysate (Adult Normal) [NBP2-11281] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Folate Binding Protein.

FOLR1 Overexpression Lysate (Native) - NBP2-11280 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Folate Binding Protein Overexpression Lysate (Adult Normal) [NBP2-11280] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Folate Binding Protein.

FOLR1 Overexpression Lysate (Native) - NBP2-10703 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Folate Binding Protein Overexpression Lysate (Adult Normal) [NBP2-10703] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Folate Binding Protein.

FOLR1 Overexpression Lysate (Native) - NBP2-11161 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Folate Binding Protein Overexpression Lysate (Adult Normal) [NBP2-11161] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Folate Binding Protein.

FOLR1 Overexpression Lysate (Native) - NBP2-11283 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

FOLR1 Overexpression Lysate (Native) - NBP2-11282 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

FOLR1 Overexpression Lysate (Native) - NBP2-06996 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

Human FOLR1 Human Cells Transfected Lysate (positive control) (denatured) - orb173647 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

FOLR1-knockout Cell lysate - LC810083 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human FOLR1 Knockdown Stable Cell Line - CSC-DC005826 from Creative biogene

Category Cell Line
Species Human

Human FOLR1 Knockout Cell Line-HeLa - CSC-RT0534 from Creative biogene

Category Cell Line
Species Human

FOLR1 KO Cell Lysate-HeLa - CLKO-0039 from Creative biogene

Category Cell Lysate
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