FOLR1

Gene Symbol	FOLR1
Entrez Gene	2348
Alt Symbol	FBP, FOLR
Species	Human
Gene Type	protein-coding
Description	folate receptor 1 (adult)
Other Description	FR-alpha|KB cells FBP|adult folate-binding protein|folate binding protein|folate receptor alpha|folate receptor, adult|ovarian tumor-associated antigen MOv18
Swissprots	Q6LC90 Q53EW2 Q9UCT2 Q6FGT8 P15328
Accessions	AAB05827 EAW74848 EAW74849 EAW74850 EAW74851 EAW74852 P15328 AF000381 AAB81938 AK223527 BAD97247 BC002947 AAH02947 BT007158 AAP35822 CA450368 CR542019 CAG46816 DQ892744 ABM83670 DQ895990 ABM86943 J05013 AAA35823 M25317 AAA74896 M28099 AAA35822 M35069 AAA35824 S73474 AAB31702 S73490 AAB31700 U78793 AAB39751 U78794 AAB39752 X62753 CAA44610 NM_000802 NP_000793 NM_016724 NP_057936 NM_016725 NP_057937 NM_016729 NP_057941 NM_016730
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. {ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane {ECO:0000250}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Tissue Specificity	Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:2768245, ECO:0000269|PubMed:9063895}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active cow Folate Binding Protein full length protein - ab82272 from Abcam Category Protein Prices $785.00 Sizes 1 mg Source Native Species Bovine

Active human Folate Binding Protein protein fragment - ab167698 from Abcam Category Protein Prices $302.00 Sizes 100 µg Source HEK 293 cells Species Human

Active mouse Folate Binding Protein protein fragment - ab168704 from Abcam Category Protein Source HEK 293 cells Species Mouse

Human Folate Binding Protein full length protein - ab202257 from Abcam Category Protein Source E. coli Species Human

Human Folate Binding Protein peptide - ab87124 from Abcam Category Peptide

FOLR1 / Folate Receptor Alpha Antibody Blocking Peptide - LS-E414 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOLR1 / Folate Receptor Alpha Antibody Blocking Peptide - LS-E15240 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOLR1 Recombinant Protein - H00002348-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

FOLR1-Antibody-N-term-Blocking-peptide - BP10693a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOLR1-Antibody-N-term-Blocking-Peptide - BP18815a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human FOLR1, CF - 5646-FR-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg25-Met233, with a C-terminal 6x-His tag

Folate Binding Protein (Bovine) (OPMA04283) - OPMA04283 from Aviva Systems Biology Category Protein Prices $630.00 Sizes 1 mg Source Bovine milk Species Bovine

Canine FOLR1 (His Tag) protein - orb232687 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg

Human FOLR1 His tag protein - orb84086 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Species Human

Canine FOLR1 (Fc Tag) protein - orb232686 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg

FOLR1 peptide - orb217299 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg

FOLR1 Blocking Peptide - 33R-3731 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FOLR1 protein (His tag) - 80R-4073 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Human FOLR1 Protein - abx066678 from Abbexa Category Protein Source E.coli Species Human

Folate receptor alpha (25-234, His-tag) - AR51758PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Folate receptor alpha (25-234, His-tag) - AR51758PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Folate Receptor 1, Adult (FOLR1), Human - 20-9074 from ARP American Research Products Category Protein Prices $395.00 Sizes 50 µg Source E.coli Species Human

FOLR1 Recombinant Protein - 96-323 from ProSci Category Protein Prices $350.00 Sizes 100 µg Source HEK293 cells Species Human

FOLR1 Recombinant Protein - 96-324 from ProSci Category Protein Prices $375.00 Sizes 25 µg Source HEK293 cells Species Human

FOLR1 fusion protein - Ag19959 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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