FOLR1

Gene Symbol	FOLR1
Entrez Gene	2348
Alt Symbol	FBP, FOLR
Species	Human
Gene Type	protein-coding
Description	folate receptor 1 (adult)
Other Description	FR-alpha|KB cells FBP|adult folate-binding protein|folate binding protein|folate receptor alpha|folate receptor, adult|ovarian tumor-associated antigen MOv18
Swissprots	Q6LC90 Q53EW2 Q9UCT2 Q6FGT8 P15328
Accessions	AAB05827 EAW74848 EAW74849 EAW74850 EAW74851 EAW74852 P15328 AF000381 AAB81938 AK223527 BAD97247 BC002947 AAH02947 BT007158 AAP35822 CA450368 CR542019 CAG46816 DQ892744 ABM83670 DQ895990 ABM86943 J05013 AAA35823 M25317 AAA74896 M28099 AAA35822 M35069 AAA35824 S73474 AAB31702 S73490 AAB31700 U78793 AAB39751 U78794 AAB39752 X62753 CAA44610 NM_000802 NP_000793 NM_016724 NP_057936 NM_016725 NP_057937 NM_016729 NP_057941 NM_016730
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. {ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane {ECO:0000250}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Tissue Specificity	Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:2768245, ECO:0000269|PubMed:9063895}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FOLR1 (NP_000793) VersaClone cDNA - RDC0993 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

Human FOLR1 ORF clone - CDCL109071 from Creative Biomart Species Human Accession NM_000802

Human FOLR1 ORF clone - CDCL109072 from Creative Biomart Species Human Accession NM_000802

Human FOLR1 ORF clone(NM_016725.2) - CDCG004276 from Creative Biomart Species Human Accession NM_016725.2

Human FOLR1 ORF Clone(NM_000802.3) - CDCL163895 from Creative Biomart Species Human Accession NM_000802.3

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone in cloning vector - HG11241-M from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11241-CY from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid - HG11241-UT from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11241-ACR from Sino Biological Species Human

Human FOLR1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-tagged - HG11241-NF from Sino Biological Species Human Accession NM_016725.1

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11241-NM from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11241-CF from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11241-NY from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11241-CM from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11241-NH from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11241-CH from Sino Biological Species Human

Human Folate Binding Protein/FOLR1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11241-ACG from Sino Biological Species Human

Human FOLR1 ORF clone(NM_016725.2) - CDCG004276 from Creative biogene Species Human

Human FOLR1 ORF clone (NM_016725.1) - CDCB160426 from Creative biogene Species Human

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