HPGDS

Gene Symbol	HPGDS
Entrez Gene	27306
Alt Symbol	GSTS, GSTS1, GSTS1-1, PGD2, PGDS
Species	Human
Gene Type	protein-coding
Description	hematopoietic prostaglandin D synthase
Other Description	GST class-sigma|glutathione S-transferase sigma|glutathione-dependent PGD synthase|glutathione-dependent PGD synthetase|glutathione-requiring prostaglandin D synthase|hematopoietic prostaglandin D2 synthase|prostaglandin-H2 D-isomerase
Swissprots	O60760 Q6FHT9
Accessions	AAY40905 BAA96854 EAX06052 O60760 AK290075 BAF82764 BC020734 AAH20734 CB988786 CR541662 CAG46463 CR541679 CAG46480 D82073 BAA25545 XM_005262932 XP_005262989 NM_014485 NP_055300
Function	Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9353279}.
Tissue Specificity	Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PGDS 293T Cell Transient Overexpression Lysate(Denatured) - H00027306-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

HPGDS overexpression lysate - LY415244 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HPGDS 293 Cell Lysate - 407182 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Hematopoietic Prostaglandin D Synthase/HPGDS Overexpression Lysate (Native) - NBL1-14330 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

HPGDS Over-expression Lysate Product - GWB-3CF240 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Hematopoietic Prostaglandin D Synthase/HPGDS Overexpression Lysate (Denatured) - H00027306-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human HPGDS Knockdown Stable Cell Line - CSC-DC007229 from Creative biogene Category Cell Line Species Human

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