HPGDS

Gene Symbol HPGDS
Entrez Gene 27306
Alt Symbol GSTS, GSTS1, GSTS1-1, PGD2, PGDS
Species Human
Gene Type protein-coding
Description hematopoietic prostaglandin D synthase
Other Description GST class-sigma|glutathione S-transferase sigma|glutathione-dependent PGD synthase|glutathione-dependent PGD synthetase|glutathione-requiring prostaglandin D synthase|hematopoietic prostaglandin D2 synthase|prostaglandin-H2 D-isomerase
Swissprots O60760 Q6FHT9
Accessions AAY40905 BAA96854 EAX06052 O60760 AK290075 BAF82764 BC020734 AAH20734 CB988786 CR541662 CAG46463 CR541679 CAG46480 D82073 BAA25545 XM_005262932 XP_005262989 NM_014485 NP_055300
Function Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9353279}.
Tissue Specificity Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
Top Pathways Arachidonic acid metabolism

PGD synthase CRISPR/Cas9 KO Plasmid (h) - sc-405437 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGD synthase HDR Plasmid (h) - sc-405437-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGD synthase Double Nickase Plasmid (h) - sc-405437-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGD synthase Double Nickase Plasmid (h2) - sc-405437-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGD synthase CRISPR Activation Plasmid (h) - sc-405437-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGD synthase CRISPR Activation Plasmid (h2) - sc-405437-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGD synthase Lentiviral Activation Particles (h) - sc-405437-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGD synthase Lentiviral Activation Particles (h2) - sc-405437-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PGD synthase siRNA (h) - sc-41638 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PGD synthase shRNA Plasmid (h) - sc-41638-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PGD synthase shRNA (h) Lentiviral Particles - sc-41638-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU130171 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10276 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10276 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07123 from Sigma-Aldrich

Category miRNA

HPGDS siRNA (Human) - CRH9071 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HPGDS - MBS8226588 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HPGDS (NM_014485.2) - SHH314605 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PGDS(NM_014485.2) - SHR108888 from Creative biogene

Category siRNA
Species Reactivities Human

Human HPGDS siRNA - orb269573 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HPGDS shRNA Plasmid (Human) - CHH9071 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HPGDS miRNA 3'UTR clone - MiUTR1H-07820 from Creative biogene

Species Reactivities Human
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