HPGDS

Gene Symbol HPGDS
Entrez Gene 27306
Alt Symbol GSTS, GSTS1, GSTS1-1, PGD2, PGDS
Species Human
Gene Type protein-coding
Description hematopoietic prostaglandin D synthase
Other Description GST class-sigma|glutathione S-transferase sigma|glutathione-dependent PGD synthase|glutathione-dependent PGD synthetase|glutathione-requiring prostaglandin D synthase|hematopoietic prostaglandin D2 synthase|prostaglandin-H2 D-isomerase
Swissprots O60760 Q6FHT9
Accessions AAY40905 BAA96854 EAX06052 O60760 AK290075 BAF82764 BC020734 AAH20734 CB988786 CR541662 CAG46463 CR541679 CAG46480 D82073 BAA25545 XM_005262932 XP_005262989 NM_014485 NP_055300
Function Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9353279}.
Tissue Specificity Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
Top Pathways Arachidonic acid metabolism

PGD synthase (D-17) - sc-14816 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PGD synthase (D-17): sc-14816. Western blot analysis of PGD synthase expression in NCI-H460 whole cell lysate.

PGD synthase (FL-199) - sc-30066 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PGD synthase (FL-199): sc-30066. Western blot analysis of PGD synthase in human plasma (A) and PGD synthase expression in human adipose tissue tissue extract (B).

PGD synthase (V-17) - sc-22930 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PGD synthase (V-17): sc-22930. Immunofluorescence staining of methanol-fixed JEG-3 cells showing membrane associated localization.

Anti-Prostaglandin D Synthase (hematopoietic) antibody - ab192360 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Prostaglandin D Synthase (hematopoietic) antibody (ab192360)Lane 1 : THP1 whole cell lysateLane 2 : RAW 264.7 whole cell lysateLane 3 : PC12 whole cell lysate

Anti-Prostaglandin D Synthase (hematopoietic) antibody - ab169016 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Prostaglandin D Synthase (hematopoietic) antibody (ab169016) at 1 µg/mlLane 1 : Prostaglandin D Synthase (hematopoietic) transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-HPGDS Antibody - LS-C17378 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HPGDS Antibody - LS-C17379 from LifeSpan Bioscience

Prices $415.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal

Anti-HPGDS Antibody - LS-C342139 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HPGDS Antibody - LS-C146669 from LifeSpan Bioscience

Prices $325.00
Sizes 1 ea
Host Rabbit
Clonality Polyclonal
Western blot of HPGDS / PGDS antibody LS-C146669.

Anti-HPGDS Antibody (N-Terminus) - LS-C81292 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-HPGDS Antibody IHC-plus™ - LS-B2422 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rat
Clonality Monoclonal
Anti-HPGDS / PGDS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2422 concentration 10 ug/ml.

Anti-HPGDS Antibody (aa35-84) IHC-plus™ - LS-B6886 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HPGDS / PGDS antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6886 concentration 5 ug/ml.

Hematopoietic Prostaglandin D Synthase/HPGDS Antibody - NBP1-54625 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HPGDS Antibody [NBP1-54625] - Titration: 0.2-1 ug/ml, Positive Control: Human Spleen.

Hematopoietic Prostaglandin D Synthase/HPGDS Antibody (735301) [Unconjugated] - MAB6487 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 735301
Western blot shows lysates of NCI‑H460 human large cell lung carcinoma cell line, human lung tissue, and human placenta tissue. PVDF membrane was probed with 0.25 µg/mL of Mouse Anti-Human Hematopoietic Prostaglandin D Synthase/HPGDS Monoclonal Antibody (Catalog # MAB6487) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for Hematopoietic Prostaglandin D Synthase/HPGDS at approximately 25 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Hematopoietic Prostaglandin D Synthase/HPGDS Antibody - AF6487 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of KG‑1 human acute myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Hematopoietic Prostaglandin D Synthase/HPGDS Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6487) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Hematopoietic Prostaglandin D Synthase/HPGDS at approximately 28 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Hematopoietic Prostaglandin D Synthase/HPGDS Antibody - H00027306-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Hematopoietic Prostaglandin D Synthase/HPGDS Antibody [H00027306-B01] - analysis of PGDS expression in transfected 293T cell line by PGDS MaxPab polyclonal antibody (B01). Lane 1: PGDS transfected lysate (23.30 KDa). Lane 2: Non-transfected lysate.

Hematopoietic Prostaglandin D Synthase/HPGDS Antibody - H00027306-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Hematopoietic Prostaglandin D Synthase/HPGDS Antibody [H00027306-D01P] - Analysis of PGDS expression in transfected 293T cell line by PGDS polyclonal antibody.Lane 1: PGDS transfected lysate(23.30 KDa).Lane 2: Non-transfected lysate.

Hematopoietic Prostaglandin D Synthase/HPGDS Antibody - H00027306-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Hematopoietic Prostaglandin D Synthase/HPGDS Antibody [H00027306-B01P] - Analysis of PGDS expression in transfected 293T cell line by PGDS polyclonal antibody. Lane 1: PGDS transfected lysate(21.89 KDa). Lane 2: Non-transfected lysate.

Anti-HPGDS antibody produced in rabbit - HPA024035 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HPGDS: <B>Cat. No. HPA024035</B>: Immunohistochemical staining of human bone marrow shows moderate cytoplasmic positivity in megakaryocytes.

Anti-PGDS, (N-terminal) antibody produced in rabbit - SAB2103598 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PGDS, (N-terminal): <B>Cat. No. SAB2103598</B>: Immunohistochemistry of PGDS in Lung tissue with PGDS antibody at 4-8 μg/mL.

Anti-PGDS antibody produced in mouse - SAB1409121 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PGDS: <B>Cat. No. SAB1409121</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~21.9 kDa using PGDS transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-PGDS antibody produced in rabbit - SAB1410544 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PGDS: <B>Cat. No. SAB1410544</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~23.3 kDa using PGDS transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

PGDS antibody - N-terminal region (ARP48762_P050) - ARP48762_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PGDS antibody - N-terminal region (ARP48763_P050) - ARP48763_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Human Hematopoietic Prostaglandin D Synthase/HPGDS Antibody - AF6487 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Detection of Human Hematopoietic Prostaglandin D Synthase/HPGDS by Western Blot. Western blot shows lysates of KG-1 human acute myelogenous leukemia cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Hematopoietic Prostaglandin D Synthase/HPGDS Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6487) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). A specific band was detected for Hematopoietic Prostaglandin D Synthase/HPGDS at approximately 28 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 .
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