HPGDS

Gene Symbol	HPGDS
Entrez Gene	27306
Alt Symbol	GSTS, GSTS1, GSTS1-1, PGD2, PGDS
Species	Human
Gene Type	protein-coding
Description	hematopoietic prostaglandin D synthase
Other Description	GST class-sigma|glutathione S-transferase sigma|glutathione-dependent PGD synthase|glutathione-dependent PGD synthetase|glutathione-requiring prostaglandin D synthase|hematopoietic prostaglandin D2 synthase|prostaglandin-H2 D-isomerase
Swissprots	O60760 Q6FHT9
Accessions	AAY40905 BAA96854 EAX06052 O60760 AK290075 BAF82764 BC020734 AAH20734 CB988786 CR541662 CAG46463 CR541679 CAG46480 D82073 BAA25545 XM_005262932 XP_005262989 NM_014485 NP_055300
Function	Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9353279}.
Tissue Specificity	Expressed in a number of megakaryocytic cell lines but not in platelets. Highly expressed in adipose tissue, macrophages and placenta. Also expressed at lower levels in lung, heart, lymph nodes, appendix, bone marrow and fetal liver. {ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}.
Top Pathways	Arachidonic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Prostaglandin D Synthase (hematopoietic) full length protein - ab126698 from Abcam Category Protein Source E. coli Species Human

Human Prostaglandin D Synthase (hematopoietic) full length protein - ab40116 from Abcam Category Protein Source E. coli Species Human

Human Prostaglandin D Synthase (hematopoietic) full length protein - ab172856 from Abcam Category Protein Source E. coli Species Human

Human Prostaglandin D Synthase (hematopoietic) full length protein - ab88041 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

HPGDS Antibody Blocking Peptide - LS-E17630 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HPGDS Antibody Blocking Peptide - LS-E17631 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Hematopoietic Prostaglandin D Synthase/HPGDS Recombinant Protein - H00027306-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Hematopoietic Prostaglandin D Synthase/HPGDS Protein - NBP1-98970 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

Recombinant Human HPGDS, CF - 6487-PS-010 from R&D Systems Category Protein Source E. coli-derived, Met1-Leu199, with a C-terminal 6-His tag

Human HPGDS protein - orb168514 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human HPGDS protein (His Tag) - orb139025 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source E. coli Species Human

Human Glutathione S-Transferase protein - orb163494 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

HPGDS Blocking Peptide - abx063823 from Abbexa Category Peptide Species Human, Mouse, Rat

Human PTGDS2 Protein - abx060021 from Abbexa Category Protein Source Yeast Species Human

PGD synthetase / PGDS (1-199, His-tag) - AR50381PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PGD synthetase / PGDS (1-199, His-tag) - AR50381PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PGD synthetase / PGDS - H00027306-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PGD synthetase / PGDS - H00027306-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HPGDS, 1-199aa, Human, His tag, E.coli - 01-P1557 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

PGDS, Human, Recombinant - 19-CF57 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

PGDS fusion protein - Ag18339 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PGDS fusion protein - Ag18290 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

HPGDS Human - ENPS-623 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human HPRT1 Enzyme - BP000945-C294 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

BTP Human - GWB-AC3EE7 from Genway Biotech Category Protein Prices $75.00, $165.00, $5,950.00 Sizes 2 μg, 10 μg, 1000 μg Species Human

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