SFRP4

Gene Symbol SFRP4
Entrez Gene 6424
Alt Symbol FRP-4, FRPHE, sFRP-4
Species Human
Gene Type protein-coding
Description secreted frizzled-related protein 4
Other Description frizzled protein, human endometrium|secreted frizzled-related protein 4; secreted frizzled-related protein 4
Swissprots Q6FHM0 Q6FHJ7 Q1ZYW2 Q6PD64 Q05BG7 Q4G124 O14877 B4DYC1
Accessions EAL23981 EAW94085 Q6FHJ7 AF026692 AAC04617 AK302357 BAG63683 AK303977 BAG64896 AK313029 BC032828 BC047684 AAH47684 BC058911 AAH58911 BT019679 AAV38485 CR541731 CAG46532 CR541755 CAG46555 DQ420628 ABD83351 NM_003014 NP_003005
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. {ECO:0000250}.
Subcellular Location Secreted {ECO:0000269|PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells.
Tissue Specificity Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). {ECO:0000269|PubMed:10728394, ECO:0000269|PubMed:19480240}.
Top Pathways Wnt signaling pathway

FRP-4 (H-200) - sc-30152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FRP-4 (H-200): sc-30152. Western blot analysis of FRP-4 expression in non-transfected: sc-117752 (A) and human FRP-4 transfected: sc-116599 (B) 293T whole cell lysates.

FRP-4 (L-20) - sc-20600 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FRP-4 (N-19) - sc-22498 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SFRP4 antibody - ab32784 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SFRP4 antibody (ab32784) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-SFRP4 antibody [EPR9389] - ab154167 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9389
All lanes : Anti-SFRP4 antibody [EPR9389] (ab154167) at 1/1000 dilutionLane 1 : Human ovary cancer lysateLane 2 : Human uterus cancer lysateLane 3 : MCF7 lysateLane 4 : 293T lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-SFRP4 Antibody - LS-C10139 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-SFRP4 Antibody (aa318-346, AP) - LS-C224041 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa318-346, APC) - LS-C224042 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa318-346, Biotin) - LS-C224043 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa318-346, FITC) - LS-C224044 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa318-346, Azide-free, HRP) - LS-C224047 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa318-346, PE) - LS-C227058 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa265-346, Biotin) - LS-C298494 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa167-260, Biotin) - LS-C299990 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa25-222, Biotin) - LS-C299992 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa27-154, Biotin) - LS-C300341 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa27-154, FITC) - LS-C303701 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa167-260, FITC) - LS-C304163 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa25-222, FITC) - LS-C304166 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa265-346, FITC) - LS-C305148 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa265-346) - LS-C296343 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SFRP4.

Anti-SFRP4 Antibody (aa318-346) - LS-C169015 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SFRP4 Antibody western blot of K562 cell line lysates (35 ug/lane). The SFRP4 antibody detected the SFRP4 protein (arrow).

Anti-SFRP4 Antibody (aa325-354) - LS-C325038 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SFRP4 Antibody (aa27-154) - LS-C296344 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SFRP4.

Anti-SFRP4 Antibody (aa167-260) - LS-C296345 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SFRP4.
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