SFRP4

Gene Symbol	SFRP4
Entrez Gene	6424
Alt Symbol	FRP-4, FRPHE, sFRP-4
Species	Human
Gene Type	protein-coding
Description	secreted frizzled-related protein 4
Other Description	frizzled protein, human endometrium|secreted frizzled-related protein 4; secreted frizzled-related protein 4
Swissprots	Q6FHM0 Q6FHJ7 Q1ZYW2 Q6PD64 Q05BG7 Q4G124 O14877 B4DYC1
Accessions	EAL23981 EAW94085 Q6FHJ7 AF026692 AAC04617 AK302357 BAG63683 AK303977 BAG64896 AK313029 BC032828 BC047684 AAH47684 BC058911 AAH58911 BT019679 AAV38485 CR541731 CAG46532 CR541755 CAG46555 DQ420628 ABD83351 NM_003014 NP_003005
Function	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells.
Tissue Specificity	Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). {ECO:0000269|PubMed:10728394, ECO:0000269|PubMed:19480240}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SFRP4-cDNA-Clone - DC08143 from Abgent, a WuXi AppTec company Prices $467.10 Sizes 10 µg Species Human Accession BC058911

SFRP4 - MBS1267299 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC058911

Human SFRP4 ORF Clone(NM_003014.3) - CDCL175220 from Creative Biomart Species Human Accession NM_003014.3

Human SFRP4 ORF Clone(NM_003014.3) - CDCL175221 from Creative Biomart Species Human Accession NM_003014.3

human SFRP4 ORF clone - CDCH079258 from Creative Biomart Species Human Accession NM_003014

human SFRP4 ORF clone - CDCH079259 from Creative Biomart Species Human Accession NM_003014

human SFRP4 ORF clone - CDCH079260 from Creative Biomart Species Human Accession NM_003014

human SFRP4 ORF clone - CDCH079261 from Creative Biomart Species Human Accession NM_003014

Human sFRP-4 Gene cDNA clone plasmid - HG10717-U from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, C-His tag - HG10717-CH from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10717-ACR from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid - HG10717-UT from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10717-ACG from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, N-His tag - HG10717-NH from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10717-NF from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10717-NM from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10717-CF from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10717-CY from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10717-CM from Sino Biological Species Human

Human SFRP4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10717-NY from Sino Biological Species Human

Human sFRP-4 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10717-U-F from Sino Biological Species Human Accession NM_003014.3

Human SFRP4 Gene ORF cDNA clone expression plasmid, C-His tag - HG10717-U-H from Sino Biological Species Human

Human sFRP-4 ORF clone(NM_003014.3) - CDCL186162 from Creative biogene Species Human

Human SFRP4 ORF Clone (BC058911) - CDCS411099 from Creative biogene Species Human Accession Q6FHJ7

Human sFRP-4 ORF Expression Clone, His-tagged - orb145243 from Biorbyt Prices $570.00 Sizes 10 μg Species Human

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