SFRP4

Gene Symbol	SFRP4
Entrez Gene	6424
Alt Symbol	FRP-4, FRPHE, sFRP-4
Species	Human
Gene Type	protein-coding
Description	secreted frizzled-related protein 4
Other Description	frizzled protein, human endometrium|secreted frizzled-related protein 4; secreted frizzled-related protein 4
Swissprots	Q6FHM0 Q6FHJ7 Q1ZYW2 Q6PD64 Q05BG7 Q4G124 O14877 B4DYC1
Accessions	EAL23981 EAW94085 Q6FHJ7 AF026692 AAC04617 AK302357 BAG63683 AK303977 BAG64896 AK313029 BC032828 BC047684 AAH47684 BC058911 AAH58911 BT019679 AAV38485 CR541731 CAG46532 CR541755 CAG46555 DQ420628 ABD83351 NM_003014 NP_003005
Function	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells.
Tissue Specificity	Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). {ECO:0000269|PubMed:10728394, ECO:0000269|PubMed:19480240}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SFRP4 full length protein - ab167942 from Abcam Category Protein Source HEK 293 cells Species Human

Human SFRP4 full length protein - ab191987 from Abcam Category Protein Source HEK 293 cells Species Human

Human SFRP4 peptide - ab32783 from Abcam Category Peptide

Human SFRP4 protein fragment - ab114483 from Abcam Category Protein Source Wheat germ Species Human

SFRP4 Antibody Blocking Peptide - LS-E1082 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SFRP4 Antibody Blocking Peptide - LS-E26956 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

sFRP-4 Partial Recombinant Protein - H00006424-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SFRP4-Antibody-C-term-Blocking-peptide - BP11574b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SFRP4-Antibody-Center-Blocking-Peptide - BP14479c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SFRP4 blocking peptide - GTX88477-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Pig, Rat, Bovine

Recombinant Human sFRP-4 - 1827-SF-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala22-Val346, with a C-terminal 10-His tag

Recombinant Human sFRP-4, CF - 1827-SF-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala22-Val346, with a C-terminal 10-His tag

Human FRP-4 protein - orb83120 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Human Species Human

Human SFRP4 protein - orb191269 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli Species Human

Human sFRP4 (His Tag) protein - orb179667 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source CHO Stable Cells Species Human

SFRP4 peptide - orb73193 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Goat anti SFRP4 antibody Immunizing peptide - orb55068 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human SFRP4 Protein - abx068995 from Abbexa Category Protein Source E.coli Species Human

Human SFRP4 Protein - abx068992 from Abbexa Category Protein Source E.coli Species Human

SFRP4 Peptide - AC21-1784-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SFRP4 - H00006424-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SFRP4 - H00006424-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Secreted Frizzled Related Protein 4 (SFRP4), Human - 20-9132 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

Secreted Frizzled Related Protein 4 (SFRP4), Human - 20-9133 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

SFRP4 fusion protein - ag6909 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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