SFRP4
| Gene Symbol | SFRP4 |
|---|---|
| Entrez Gene | 6424 |
| Alt Symbol | FRP-4, FRPHE, sFRP-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | secreted frizzled-related protein 4 |
| Other Description | frizzled protein, human endometrium|secreted frizzled-related protein 4; secreted frizzled-related protein 4 |
| Swissprots | Q6FHM0 Q6FHJ7 Q1ZYW2 Q6PD64 Q05BG7 Q4G124 O14877 B4DYC1 |
| Accessions | EAL23981 EAW94085 Q6FHJ7 AF026692 AAC04617 AK302357 BAG63683 AK303977 BAG64896 AK313029 BC032828 BC047684 AAH47684 BC058911 AAH58911 BT019679 AAV38485 CR541731 CAG46532 CR541755 CAG46555 DQ420628 ABD83351 NM_003014 NP_003005 |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells. |
| Tissue Specificity | Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). {ECO:0000269|PubMed:10728394, ECO:0000269|PubMed:19480240}. |
| Top Pathways | Wnt signaling pathway |
FRP-4 CRISPR/Cas9 KO Plasmid (h) - sc-405677 from Santa Cruz Biotechnology
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FRP-4 HDR Plasmid (h) - sc-405677-HDR from Santa Cruz Biotechnology
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FRP-4 Double Nickase Plasmid (h) - sc-405677-NIC from Santa Cruz Biotechnology
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FRP-4 Double Nickase Plasmid (h2) - sc-405677-NIC-2 from Santa Cruz Biotechnology
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FRP-4 CRISPR Activation Plasmid (h) - sc-405677-ACT from Santa Cruz Biotechnology
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FRP-4 CRISPR Activation Plasmid (h2) - sc-405677-ACT-2 from Santa Cruz Biotechnology
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FRP-4 Lentiviral Activation Particles (h) - sc-405677-LAC from Santa Cruz Biotechnology
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FRP-4 Lentiviral Activation Particles (h2) - sc-405677-LAC-2 from Santa Cruz Biotechnology
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FRP-4 siRNA (h) - sc-40002 from Santa Cruz Biotechnology
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FRP-4 shRNA Plasmid (h) - sc-40002-SH from Santa Cruz Biotechnology
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FRP-4 shRNA (h) Lentiviral Particles - sc-40002-V from Santa Cruz Biotechnology
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sFRP-4 RNAi - H00006424-R01 from Novus Biologicals
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MISSION® esiRNA - EHU012841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19198 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19198 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09575 from Sigma-Aldrich
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SFRP4 siRNA (Human) - CRH4339 from Cohesion Biosciences
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SFRP4 - MBS8225714 from MyBioSource
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shRNA set against Human SFRP4 (NM_003014.3) - SHH405964 from Creative biogene
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Human SFRP4 siRNA - orb264841 from Biorbyt
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SFRP4 shRNA Plasmid (Human) - CHH4339 from Cohesion Biosciences
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SFRP4 miRNA 3'UTR clone - MiUTR3H-08575 from Creative biogene
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