SFRP4

Gene Symbol	SFRP4
Entrez Gene	6424
Alt Symbol	FRP-4, FRPHE, sFRP-4
Species	Human
Gene Type	protein-coding
Description	secreted frizzled-related protein 4
Other Description	frizzled protein, human endometrium|secreted frizzled-related protein 4; secreted frizzled-related protein 4
Swissprots	Q6FHM0 Q6FHJ7 Q1ZYW2 Q6PD64 Q05BG7 Q4G124 O14877 B4DYC1
Accessions	EAL23981 EAW94085 Q6FHJ7 AF026692 AAC04617 AK302357 BAG63683 AK303977 BAG64896 AK313029 BC032828 BC047684 AAH47684 BC058911 AAH58911 BT019679 AAV38485 CR541731 CAG46532 CR541755 CAG46555 DQ420628 ABD83351 NM_003014 NP_003005
Function	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:19480240}. Note=Cytoplasmic in ovarian tumor cells.
Tissue Specificity	Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). {ECO:0000269|PubMed:10728394, ECO:0000269|PubMed:19480240}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SFRP4 Lysate (Non-Denatured) - L139T6 from Acris Antibodies Category Cell Lysate Prices $290.00 Sizes 100 µg

SFRP4 overexpression lysate - LY401054 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SFRP4 293 Cell Lysate - 400987 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

sFRP-4 Overexpression Lysate (Native) - NBL1-15885 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FRP-4 (h): 293T Lysate - sc-116599 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SFRP4 Over-expression Lysate Product - GWB-47BE2D from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human sFRP4 CHO Cell Lysate (WB positive control) - 10717-H08SL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human sFRP4 HEK293 Cell Lysate (WB positive control) - 10717-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human sFRP4 Human Cells Transfected Lysate (positive control) (denatured) - orb173007 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Panoply™ Human SFRP4 Knockdown Stable Cell Line - CSC-DC014111 from Creative biogene Category Cell Line Species Human

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