GPC1

Gene Symbol GPC1
Entrez Gene 2817
Alt Symbol glypican
Species Human
Gene Type protein-coding
Description glypican 1
Other Description glypican proteoglycan 1|glypican-1
Swissprots Q53QM4 P35052 B3KTD1
Accessions AAY24160 CAI93681 EAW71180 EAW71181 EAW71182 EAW71183 EAW71184 P35052 AB209122 BAD92359 AK095397 BAG53043 AK096638 BAG53345 AK223516 BAD97236 BC008123 BC027997 AAH27997 BC045712 BC051279 AAH51279 BG825129 X54232 CAA38139 XM_011510976 XP_011509278 NM_002081 NP_002072
Function Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP Abeta peptides in lipid rafts in Alzheimer disease brains.
Top Pathways Proteoglycans in cancer

glypican-1 (A-10) - sc-365000 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
glypican-1 (A-10): sc-365000. Western blot analysis of glypican-1 expression in K-562 (A), LADMAC (B) and MIA PaCa-2 (C) whole cell lysates.

glypican-1 (9E9) - sc-101826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

glypican-1 (4D1) - sc-101827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
glypican-1 (4D1): sc-101827. Western blot analysis of glypican-1 expression in K-562 (A) and MIA PaCa-2 (B) whole cell lysates.

glypican-1 (C-18) - sc-14648 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

glypican-1 (E-18) - sc-14646 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
glypican-1 (E-18): sc-14646. Western blot analysis of glypican-1 expression in K-562 (A) and LADMAC (B) whole cell lysates.

glypican-1 (H-95) - sc-66909 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
glypican-1 (H-95): sc-66909. Western blot analysis of glypican-1 expression in LADMAC whole cell lysate.

glypican-1 (M-95) - sc-66910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
glypican-1 (M-95): sc-66910. Western blot analysis of glypican-1 expression in mouse brain tissue extract.

glypican-1 (K-17) - sc-48516 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
glypican-1 (K-17): sc-48516. Western blot analysis of glypican-1 expression in RAW 264.7 whole cell lysate.

glypican-1 (N-14) - sc-48517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
glypican-1 (N-14): sc-48517. Western blot analysis of glypican-1 expression in Daudi whole cell lysate.

glypican-1 (N-16) - sc-14645 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

glypican-1 (S-16) - sc-33923 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
glypican-1 (S-16): sc-33923. Western blot analysis of mouse recombinant glypican-1 fusion protein.

glypican-1 (T-17) - sc-14647 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
glypican-1 (T-17): sc-14647. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of decidual cells.

Anti-Glypican 1/ GPC1 antibody - ab55971 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Glypican 1/ GPC1 antibody (ab55971) at 1/2000 dilution + lysate prepared from ScN2a cells.Secondaryperoxidase-conjugated secondarydeveloped using the ECL technique

Anti-Glypican 1/ GPC1 antibody - ab73979 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab73979 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab73979, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-GPC1 / Glypican Antibody (C-Terminus) - LS-C46968 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPC1 / Glypican Antibody - LS-C125679 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GPC1 / Glypican Antibody (Internal) - LS-C129383 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPC1 / Glypican Antibody (N-Terminus) - LS-C144854 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GPC1 / Glypican Antibody (clone 9E9) - LS-C153072 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 9E9

Anti-GPC1 / Glypican Antibody (aa114-277, Biotin) - LS-C298960 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPC1 / Glypican Antibody (aa343-545, Biotin) - LS-C298962 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPC1 / Glypican Antibody (aa155-292, Biotin) - LS-C299781 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPC1 / Glypican Antibody (aa155-292, FITC) - LS-C303463 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPC1 / Glypican Antibody (aa155-292) - LS-C294306 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant GPC1 / Glypican.

Anti-GPC1 / Glypican Antibody (aa114-277) - LS-C294304 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant GPC1 / Glypican.
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