GPC1

Gene Symbol	GPC1
Entrez Gene	2817
Alt Symbol	glypican
Species	Human
Gene Type	protein-coding
Description	glypican 1
Other Description	glypican proteoglycan 1|glypican-1
Swissprots	Q53QM4 P35052 B3KTD1
Accessions	AAY24160 CAI93681 EAW71180 EAW71181 EAW71182 EAW71183 EAW71184 P35052 AB209122 BAD92359 AK095397 BAG53043 AK096638 BAG53345 AK223516 BAD97236 BC008123 BC027997 AAH27997 BC045712 BC051279 AAH51279 BG825129 X54232 CAA38139 XM_011510976 XP_011509278 NM_002081 NP_002072
Function	Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP Abeta peptides in lipid rafts in Alzheimer disease brains.
Top Pathways	Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GPC1 / Glypican ELISA Kit (Sandwich ELISA) - LS-F4400 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.29 ng/ml Range 0.781-50 ng/ml

Mouse GPC1 / Glypican ELISA Kit (Sandwich ELISA) - LS-F7158 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 31 pg/ml Range 0.781-50 ng/ml

Human Glypican 1 ELISA Kit - abx151692 from Abbexa Category ELISA Kit Sensitivity 6.5 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Glypican 1 (GPC1), Human, ELISA Kit - CSB-EL009703HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Glypican 1 (GPC1), Human, ELISA Kit - SEB032Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 29pg/mL Range 78-5,000pg/mL

Glypican 1, Human, ELISA Kit - E01G0226 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/ml

Glypican-1, GPC1, Human, ELISA Kit - E9038h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/ml

Glypican 1, GPC1, Human, ELISA Kit - E-EL-H1710 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

Glypican 1, GPC1, Rabbit, ELISA Kit - E-EL-RB1864 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Glypican 1, GPC1, Chicken, ELISA Kit - E-EL-Ch1920 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Glypican 1, GPC1, Porcine, ELISA Kit - E-EL-P0789 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Glypican 1, GPC1, Guinea Pig, ELISA Kit - E-EL-GP1264 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Glypican 1, GPC1, Monkey, ELISA Kit - E-EL-MK2075 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Custom Human Glypican 1 ELISA - ELH-GPC1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human GPC1 ELISA Kit - HG0233 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine GPC1 ELISA Kit - AG0233 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human GPC1(Glypican 1) ELISA Kit - E-EL-H1710 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

Human GPC1 (Glypican 1) CLIA Kit - E-CL-H1074 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

Glypican 1, ELISA Kit - MBS283136 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glypican 1, ELISA Kit - MBS086273 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glypican 1, ELISA Kit - MBS728836 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glypican 1, ELISA Kit - MBS736774 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glypican 1, ELISA Kit - MBS735763 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glypican 1, ELISA Kit - MBS020249 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Glypican 1, ELISA Kit - MBS071478 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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