GPC1

Gene Symbol GPC1
Entrez Gene 2817
Alt Symbol glypican
Species Human
Gene Type protein-coding
Description glypican 1
Other Description glypican proteoglycan 1|glypican-1
Swissprots Q53QM4 P35052 B3KTD1
Accessions AAY24160 CAI93681 EAW71180 EAW71181 EAW71182 EAW71183 EAW71184 P35052 AB209122 BAD92359 AK095397 BAG53043 AK096638 BAG53345 AK223516 BAD97236 BC008123 BC027997 AAH27997 BC045712 BC051279 AAH51279 BG825129 X54232 CAA38139 XM_011510976 XP_011509278 NM_002081 NP_002072
Function Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP Abeta peptides in lipid rafts in Alzheimer disease brains.
Top Pathways Proteoglycans in cancer

GPC1 overexpression lysate - LY419549 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

Glypican 1 Overexpression Lysate (Native) - NBP2-10795 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Glypican 1/GPC1 Overexpression Lysate (Native) [NBP2-10795] - Glypican 1/GPC1 Overexpression Lysate (Native) Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Glypican 1/ GPC1.

Panoply™ Human GPC1 Knockdown Stable Cell Line - CSC-DC006483 from Creative biogene

Category Cell Line
Species Human
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