GPC1
| Gene Symbol | GPC1 |
|---|---|
| Entrez Gene | 2817 |
| Alt Symbol | glypican |
| Species | Human |
| Gene Type | protein-coding |
| Description | glypican 1 |
| Other Description | glypican proteoglycan 1|glypican-1 |
| Swissprots | Q53QM4 P35052 B3KTD1 |
| Accessions | AAY24160 CAI93681 EAW71180 EAW71181 EAW71182 EAW71183 EAW71184 P35052 AB209122 BAD92359 AK095397 BAG53043 AK096638 BAG53345 AK223516 BAD97236 BC008123 BC027997 AAH27997 BC045712 BC051279 AAH51279 BG825129 X54232 CAA38139 XM_011510976 XP_011509278 NM_002081 NP_002072 |
| Function | Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}. |
| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP Abeta peptides in lipid rafts in Alzheimer disease brains. |
| Top Pathways | Proteoglycans in cancer |
glypican-1 CRISPR/Cas9 KO Plasmid (h) - sc-402002 from Santa Cruz Biotechnology
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glypican-1 HDR Plasmid (h) - sc-402002-HDR from Santa Cruz Biotechnology
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glypican-1 Double Nickase Plasmid (h) - sc-402002-NIC from Santa Cruz Biotechnology
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glypican-1 Double Nickase Plasmid (h2) - sc-402002-NIC-2 from Santa Cruz Biotechnology
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glypican-1 CRISPR Activation Plasmid (h) - sc-402002-ACT from Santa Cruz Biotechnology
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glypican-1 CRISPR Activation Plasmid (h2) - sc-402002-ACT-2 from Santa Cruz Biotechnology
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glypican-1 Lentiviral Activation Particles (h) - sc-402002-LAC from Santa Cruz Biotechnology
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glypican-1 Lentiviral Activation Particles (h2) - sc-402002-LAC-2 from Santa Cruz Biotechnology
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glypican-1 siRNA (h) - sc-40638 from Santa Cruz Biotechnology
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glypican-1 shRNA Plasmid (h) - sc-40638-SH from Santa Cruz Biotechnology
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glypican-1 shRNA (h) Lentiviral Particles - sc-40638-V from Santa Cruz Biotechnology
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Glypican 1 RNAi - H00002817-R01 from Novus Biologicals
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MISSION® esiRNA - EHU154321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9513 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9513 from Sigma-Aldrich
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GPC1 siRNA (Human) - CRH1883 from Cohesion Biosciences
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GPC1 - MBS8234261 from MyBioSource
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shRNA set against Human GPC1 (NM_002081.2) - SHH305738 from Creative biogene
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shRNA set against Human GPC1(NM_002081.2) - SHH095789 from Creative biogene
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Human GPC1 siRNA - orb262385 from Biorbyt
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GPC1 shRNA Plasmid (Human) - CHH1883 from Cohesion Biosciences
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GPC1 miRNA 3'UTR clone - MiUTR1H-04160 from Creative biogene
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