GPC1

Gene Symbol	GPC1
Entrez Gene	2817
Alt Symbol	glypican
Species	Human
Gene Type	protein-coding
Description	glypican 1
Other Description	glypican proteoglycan 1|glypican-1
Swissprots	Q53QM4 P35052 B3KTD1
Accessions	AAY24160 CAI93681 EAW71180 EAW71181 EAW71182 EAW71183 EAW71184 P35052 AB209122 BAD92359 AK095397 BAG53043 AK096638 BAG53345 AK223516 BAD97236 BC008123 BC027997 AAH27997 BC045712 BC051279 AAH51279 BG825129 X54232 CAA38139 XM_011510976 XP_011509278 NM_002081 NP_002072
Function	Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP Abeta peptides in lipid rafts in Alzheimer disease brains.
Top Pathways	Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Glypican 1/ GPC1 protein fragment - ab114484 from Abcam Category Protein Source Wheat germ Species Human

GPC1 / Glypican Blocking Peptide - LS-E9977 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Glypican 1 Protein - H00002817-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Glypican-1-Antibody-N-term-Blocking-Peptide - BP9163a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Glypican 1, CF - 4519-GP-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Asp24-Ser530, with a C-terminal 6-His tag

Human Glypican 1 Protein - abx066889 from Abbexa Category Protein Source E.coli Species Human

Glypican-1 / GPC1 - H00002817-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Glypican-1 / GPC1 - H00002817-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Glypican 1 (GPC1), Human - 20-7413 from ARP American Research Products Category Protein Prices $369.00 Sizes 50 µg Source E.coli Species Human

GPC1 fusion protein - ag10068 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

GPC1 fusion protein - ag10095 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human GPC1 - GPC1-29027TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Glypican 1, His-tagged - GPC1-152H from Creative Biomart Category Protein Source Mouse NSO Cells Species Human

Recombinant Glypican 1 (GPC1) - RPB032Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Glypican 1 (GPC1) - RPB032Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Glypican 1 (GPC1) - RPB032Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Glypican 1 (GPC1) - RPB032Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Glypican-1(GPC1) - CSB-YP009703HU CSB-EP009703HU CSB-BP009703HU CSB-MP009703HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Glypican 1 Protein, CF - 4519-GP from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Asp24-Ser530, with a C-terminal 6-His tag Species Human

Glypican 1 (GPC1) - RPU141713 from Biomatik Category Protein Prices $165.00, $330.00, $495.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

Glypican 1 Protein - NBP1-89759PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

GPC1 Peptide, Human - M34GP06483H from Creative Peptides Category Peptide Source Synthetic. Species Human

GPC1 protein - orb372172 from Biorbyt Category Protein Prices $782.00 Sizes 100 μg

Human GPC1 protein - orb371856 from Biorbyt Category Protein Prices $264.00, $451.00, $2,032.00, $2,882.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

GPC1 Antibody - SH-A12441 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

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