GPC1

Gene Symbol	GPC1
Entrez Gene	2817
Alt Symbol	glypican
Species	Human
Gene Type	protein-coding
Description	glypican 1
Other Description	glypican proteoglycan 1|glypican-1
Swissprots	Q53QM4 P35052 B3KTD1
Accessions	AAY24160 CAI93681 EAW71180 EAW71181 EAW71182 EAW71183 EAW71184 P35052 AB209122 BAD92359 AK095397 BAG53043 AK096638 BAG53345 AK223516 BAD97236 BC008123 BC027997 AAH27997 BC045712 BC051279 AAH51279 BG825129 X54232 CAA38139 XM_011510976 XP_011509278 NM_002081 NP_002072
Function	Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP Abeta peptides in lipid rafts in Alzheimer disease brains.
Top Pathways	Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GPC1 gene - orb91148 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human GPC1 ORF clone(NM_002081.2) - CDCL184448 from Creative Biomart Species Human Accession NM_002081.2

Human GPC1 ORF clone(NM_002081.2) - CDCG009833 from Creative Biomart Species Human Accession NM_002081.2

Human GPC1 ORF Clone(NM_002081.2) - CDCL165075 from Creative Biomart Species Human Accession NM_002081.2

Human GPC1 ORF Clone(NM_002081.2) - CDCL165076 from Creative Biomart Species Human Accession NM_002081.2

Human Glypican 1/GPC1 Gene ORF cDNA clone in cloning vector - HG10576-M from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10576-NY from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10576-CM from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10576-CH from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10576-ACR from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid - HG10576-UT from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10576-NH from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10576-ACG from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10576-NF from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10576-M-F from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10576-CY from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10576-NM from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10576-M-Y from Sino Biological Species Human

Human Glypican 1/GPC1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10576-CF from Sino Biological Species Human

Human GPC1 ORF clone(NM_002081.2) - CDCL184448 from Creative biogene Species Human

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