GAB2

Gene Symbol GAB2
Entrez Gene 9846
Alt Symbol -
Species Human
Gene Type protein-coding
Description GRB2-associated binding protein 2
Other Description GRB2-associated-binding protein 2|Grb2-associated binder 2|growth factor receptor bound protein 2-associated protein 2|pp100
Swissprots O60317 A6NEW9 Q9UQC2 A7MD36 A2RRM2
Accessions EAW75057 EAW75058 Q9UQC2 AA865573 AB011143 BAA25497 AB018413 BAA76737 AI858080 BC131711 AAI31712 BC152459 AAI52460 BY799914 DA674753 DB636423 XM_006718753 XP_006718816 XM_011545408 XP_011543710 XR_950117 NM_012296 NP_036428 NM_080491 NP_536739
Function Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19172738}. Cell membrane {ECO:0000269|PubMed:19172738}.
Top Pathways Fc epsilon RI signaling pathway, Chronic myeloid leukemia, Fc gamma R-mediated phagocytosis, Osteoclast differentiation, Sphingolipid signaling pathway

Gab 2 CRISPR/Cas9 KO Plasmid (h) - sc-402159 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gab 2 HDR Plasmid (h) - sc-402159-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gab 2 Double Nickase Plasmid (h) - sc-402159-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gab 2 Double Nickase Plasmid (h2) - sc-402159-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gab 2 CRISPR Activation Plasmid (h) - sc-402159-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gab 2 CRISPR Activation Plasmid (h2) - sc-402159-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gab 2 Lentiviral Activation Particles (h) - sc-402159-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gab 2 Lentiviral Activation Particles (h2) - sc-402159-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Gab 2 siRNA (h) - sc-40606 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Gab 2 shRNA Plasmid (h) - sc-40606-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Gab 2 shRNA (h) Lentiviral Particles - sc-40606-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU078741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9039 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9039 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GAB2 siRNA (Human) - CRH6597 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GAB2 - MBS8228539 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GAB2 (NM_012296.3) - SHH298321 from Creative biogene

Category siRNA
Species Reactivities Human

Human GAB2 siRNA - orb267099 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GAB2 shRNA Plasmid (Human) - CHH6597 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GAB2 miRNA 3'UTR clone - MiUTR4H-TG03691 from Creative biogene

Species Reactivities Human
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