GAB2

Gene Symbol GAB2
Entrez Gene 9846
Alt Symbol -
Species Human
Gene Type protein-coding
Description GRB2-associated binding protein 2
Other Description GRB2-associated-binding protein 2|Grb2-associated binder 2|growth factor receptor bound protein 2-associated protein 2|pp100
Swissprots O60317 A6NEW9 Q9UQC2 A7MD36 A2RRM2
Accessions EAW75057 EAW75058 Q9UQC2 AA865573 AB011143 BAA25497 AB018413 BAA76737 AI858080 BC131711 AAI31712 BC152459 AAI52460 BY799914 DA674753 DB636423 XM_006718753 XP_006718816 XM_011545408 XP_011543710 XR_950117 NM_012296 NP_036428 NM_080491 NP_536739
Function Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19172738}. Cell membrane {ECO:0000269|PubMed:19172738}.
Top Pathways Fc epsilon RI signaling pathway, Chronic myeloid leukemia, Fc gamma R-mediated phagocytosis, Osteoclast differentiation, Sphingolipid signaling pathway

Phospho-Gab2 (Ser159) Antibody - 3884 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from H-4-II-E cells, untreated, HGF-treated, insulin-treated or treated with lambda phosphatase after lysis, using Phospho-GAB2 (Ser159) Antibody.

Phospho-Gab2 (Tyr452) (C33G1) Rabbit mAb - 3882 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C33G1
Western blot analysis of extracts from Baf3 cells stably transfected with a construct expressing FLT3, untreated or treated with FLT ligand (FL), using Phospho-Gab2 (Tyr452) (C33G1) Rabbit mAb (upper) or Gab2 (26B6) Rabbit mAb #3239 (lower).

Phospho-Gab2 (Tyr452) Antibody - 3881 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from BaF3 cells, untreated or treated with Flt3 ligand, using Phospho-Gab2 (Tyr452) Antibody.

Gab2 (26B6) Rabbit mAb - 3239 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 26B6
Western blot analysis of cell extracts from various cell lines, using Gab2 (26B6) Rabbit mAb.

Gab 2 (H-6) - sc-365590 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Gab 2 (H-6): sc-365590. Western blot analysis of Gab 2 expression in K-562 whole cell lysate.

Gab 1/2 (I-18) - sc-9311 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Gab 1/2 (I-18): sc-9311. Western blot analysis of Gab 2 expression in K-562 whole cell lysate.

Gab 2 (H-200) - sc-25498 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Gab 2 (H-200): sc-25498. Western blot analysis of Gab 2 expression in K-562 (A), MCP-5 (B), OV-90 (C), ES-2 (D), A549 (E) and F9 (F) whole cell lysates.

Gab 2 (M-19) - sc-9313 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Gab 2 (M-19): sc-9313. Western blot analysis of Gab 2 expression in K-562 (A) and MCP-5 (B) whole cell lysates and mouse brain tissue extract (C).

Anti-GAB2 (phospho S159) antibody - ab78208 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GAB2 (phospho S159) antibody (ab78208) at 1/500 dilutionLane 1 : Extracts from HT-29 cells, treated with serum (20%, 15mins)Lane 2 : Extracts from HT-29 cells, treated with serum (20%, 15mins) plus 5µg immunizing peptideLysates/proteins at 5 µg per lane.

Anti-GAB2 (phospho S623) antibody - ab92578 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GAB2 (phospho S623) antibody (ab92578) at 1/500 dilutionLane 1 : Extracts from HepG2 cells treated with PMA (125ng/ml, 30mins) Lane 2 : Extracts from HepG2 cells, treated with PMA (125ng/ml, 30mins) with immunizing phosphopeptide at 10 µgLysates/proteins at 10 µg per lane.

Anti-GAB2 (phospho S623) antibody - ab196949 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GAB2 (phospho S623) antibody (ab196949) at 1/500 dilutionLane 1 : Extracts from Jurkat cells treated with TNF (2500U/ml, 30mins)Lane 2 : Extracts from Jurkat cells treated with TNF (2500U/ml, 30mins) with synthesized peptide

Anti-GAB2 (phospho Y452) antibody - ab203616 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GAB2 (phospho Y452) antibody (ab203616) at 1/200 dilutionLane 1 : Rat intestine lysateLane 2 : Mouse embryo lysateSecondaryGoat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/3000 dilution

Anti-GAB2 (phospho Y643) antibody - ab78262 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GAB2 (phospho Y643) antibody (ab78262) at 1/500 dilutionLane 1 : Extracts from Jurkat cells, treated with IFN (2500U/ML, 30mins)Lane 2 : Extracts from Jurkat cells, treated with IFN (2500U/ML, 30mins) plus 5µg immunizing peptideLysates/proteins at 5 µg per lane.

Anti-GAB2 antibody - ab79426 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GAB2 antibody (ab79426) at 1/500 dilutionLane 1 : Extracts from Jurkat cellsLane 2 : Extracts from Jurkat cells with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-GAB2 antibody - ab33094 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GAB2 antibody - ab62802 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-GAB2 antibody (ab62802) at 1 µg/ml + K562 cell lysate (35µg protein in RIPA buffer).

Anti-GAB2 antibody - ab169399 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-GAB2 antibody (ab169399) at 1/500 dilutionLane 1 : GAB2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-GAB2 antibody [EP369Y] - ab32365 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP369Y
All lanes : Anti-GAB2 antibody [EP369Y] (ab32365) at 1/500 dilutionLane 1 : K526 cell lysateLane 2 : MCF-7 cell lysate

Anti-GAB2 antibody [EPR2869] - ab108423 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2869
All lanes : Anti-GAB2 antibody [EPR2869] (ab108423) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : MCF7 cell lysateLane 3 : TF-1 cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.

Anti-GAB2 Antibody (phospho-Tyr452) - LS-C6999 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GAB2 Antibody (aa285-676) - LS-C7000 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-GAB2 Antibody (Leu617) - LS-C193120 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GAB2 Antibody (Arg270) - LS-C193263 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GAB2 Antibody (aa568-617) - LS-C291971 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GAB2 Antibody (aa104-153) - LS-C291973 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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