| Gene Symbol | KLHL25 |
|---|---|
| Entrez Gene | 64410 |
| Alt Symbol | ENC-2, ENC2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | kelch-like family member 25 |
| Other Description | BTB/POZ KELCH domain protein|ectoderm-neural cortex protein 2|ectodermal-neural cortex 2|kelch-like 25|kelch-like protein 25 |
| Swissprots | B3KRT7 B2RDH2 Q9H0H3 |
| Accessions | EAX01979 Q9H0H3 AK022649 BAB14155 AK056663 BAG51779 AK092231 BAG52499 AK126962 AK315541 BAG37919 AL109693 AL136796 CAB66730 AM393017 CAL37895 AM393776 CAL38651 AY764034 AAV51405 BC028100 AAH28100 DA337553 DB063745 EU446519 ABZ92048 NM_022480 NP_071925 |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. {ECO:0000269|PubMed:22578813}. |
kelch-like 25 (Drosophila) , ELISA Kit - MBS9327037 from MyBioSource
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Human KLHL25 ELISA Kit - E021404 from Biobool
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