KLHL25

Gene Symbol KLHL25
Entrez Gene 64410
Alt Symbol ENC-2, ENC2
Species Human
Gene Type protein-coding
Description kelch-like family member 25
Other Description BTB/POZ KELCH domain protein|ectoderm-neural cortex protein 2|ectodermal-neural cortex 2|kelch-like 25|kelch-like protein 25
Swissprots B3KRT7 B2RDH2 Q9H0H3
Accessions EAX01979 Q9H0H3 AK022649 BAB14155 AK056663 BAG51779 AK092231 BAG52499 AK126962 AK315541 BAG37919 AL109693 AL136796 CAB66730 AM393017 CAL37895 AM393776 CAL38651 AY764034 AAV51405 BC028100 AAH28100 DA337553 DB063745 EU446519 ABZ92048 NM_022480 NP_071925
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. {ECO:0000269|PubMed:22578813}.

KLHL25 CRISPR/Cas9 KO Plasmid (h) - sc-408083 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL25 HDR Plasmid (h) - sc-408083-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL25 Double Nickase Plasmid (h) - sc-408083-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL25 Double Nickase Plasmid (h2) - sc-408083-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL25 CRISPR Activation Plasmid (h) - sc-408083-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL25 CRISPR Activation Plasmid (h2) - sc-408083-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL25 Lentiviral Activation Particles (h) - sc-408083-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL25 Lentiviral Activation Particles (h2) - sc-408083-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KLHL25 siRNA (h) - sc-89948 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KLHL25 shRNA Plasmid (h) - sc-89948-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KLHL25 shRNA (h) Lentiviral Particles - sc-89948-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KLHL25 RNAi - H00064410-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU077811 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11284 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11284 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10060 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10060

KLHL25 siRNA (Human) - CRJ2010 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KLHL25 (NM_022480.3) - SHH326207 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KLHL25(NM_022480.3) - SHL201150 from Creative biogene

Category siRNA
Species Reactivities Human

KLHL25 shRNA Plasmid (Human) - CHJ2010 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KLHL25 miRNA 3'UTR clone - MiUTR1H-05374 from Creative biogene

Species Reactivities Human
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